Cuno, Inc.

Richard S Chesterson

Mark T Meyering

Rita J Andreoli

Eugene A Ostreicher

Todd Edward Arnold

Murtaza Amin

A substantially non-reflective, low or non-fluorescing substrate comprising a phase-inversion support and a plurality of opaque solids that are substantially chemically non-reactive with the phase inversion support and of a size sufficient to be partially or completely contained within, or intimately bound to, the phase inversion support. Methods of making and using the substantially non-reflective, low or non-fluorescing substrate are also disclosed.

Non-luminescent substrate

A microporous membrane comprising a highly electropositive hydrophilic material capable of irreversibly binding one or more nucleic acids, the membrane being useful for isolating, amplifying and detecting nucleic acids is disclosed. Methods of making the membrane and using the membrane for amplifying nucleic acids are also disclosed.

Nucleic acid binding matrix

An improved combination non-luminescent microporous membrane and solid support for use in micro-analytical diagnostic applications is disclosed. Specifically, composite microarray non-luminescent slides having a microporous membrane effectively attached by covalent bonding through a surface treatment to a substrate that prepares the substrate to sufficiently, covalently bond to the non-luminescent microporous membrane formed by a phase inversion process such that the combination produced thereby is useful in microarray applications and wherein the porous non-luminescent nylon composite microarray slides are covalently bonded to a solid base member, such as, for example, a glass or Mylar microscope slide, such that the combination produced thereby is useful in microarray applications. Apparatus and methods for fabricating lithe non-luminescent composite microarray slides are also disclosed.

Growing community of inventors

Meriden, CT, United States of America

Richard S Chesterson