The Procter Gamble Company

Genencor International, Inc.

Richard S Carpenter

Ann Margaret Wolff

Pushkaraj J Lad

Irwin J Goldstein

A cleaning composition is disclosed. The composition contains a first enzyme where the enzyme can be Endo-D, Endo-H, Endo-L, Endo-C, Endo-CII, Endo-F-Gal type, Endo-F and PNGaseF and a second enzyme where the enzyme can be a protease, lipase, nuclease, glycosidase, an enzyme different from the first enzyme, and any combination of these. The composition also contains a detergent surfactant and a builder. The composition can be used in a method for cleaning a surface on which is bound a glycoside-containing substance. The substance can be blood or components thereof, fecal matter or components thereof or microorganisms. The surface can be fabric, biological tissue, tooth enamel, contact lens, glass, ceramic, metal, metal alloy, plastic, plant, fruit and vegetable.

Cleaning composition containing a type II endoglycosidase

An antimicrobial composition consisting essentially of from about 1 ppm to about 1200 ppm of a Type II endoglycosidase and from about 0.5 ppm to about 1200 ppm of an antimicrobial agent is disclosed. The preferred Type II endoglycosidases to be used in the invention are Endo-D, Endo-H, Endo-F and PNGaseF. The preferred antimicrobial agents are bactericides, fungicides and algicides. The composition can be used in the form of personal care or household cleaning products such as liquid soap, hard surface cleaner, laundry detergent, anti-acne medication, deodorant, shampoo, face cream, mouthwash, dentifrice and denture cleaner.

Antimicrobial composition containing Type II endoglycosidase and

Microorganisms are removed from the surface of materials such as fabrics or contact lenses by treatment with a Type II endoglycosidase. The Type II endoglycosidase may be used alone or in combination with other enzymes, detergents, surfactants and/or disulfide cleaving reagents to facilitate removal of the microorganisms. The Type II endoglycosidase may be an Endo-.beta.-N-acetylglucosaminidase, Endo-.alpha.-N-acetylgalactosaminidase or Endo-.beta.-N-galactosidase.

Method of removing microorganisms from surfaces with Type II

A method for cleaning a surface on which is bound a glycoside-containing substance. The substance can be blood or components thereof, fecal matter or components thereof or microorganisms. The surface can be fabric, biological tissue, tooth enamel, contact lens, glass, ceramic, metal, metal alloy, plastic, plant, fruit and vegetable. A Type II endoglycosidase is used to carry out the method.

Method for cleaning a surface on which is bound a glycoside-containing

An antimicrobial composition comprising endo-.beta.-N-acetylglucosaminidase and/or endoglycopeptidase, and ruminant stomach lysozyme is presented. A method for destroying or removing microbes by treatment with these enzymes is also presented.

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Cincinnati, OH, United States of America

Richard S Carpenter