The State University of New York

Los Alamos National Security, LLC

University of Florida Research Foundation Inc

Research Foundation of Mental Hygiene Inc.

Richard Rubenstein

Martin S Piltch

Perry Clayton Gray

Kevin Ka-Wang Wang

Henryk M Wisniewski

Zhihui Yang

Maria Tonna-DeMasi

Patricia A Merz

Robert W Carpenter, Ii

Richard J Kascsak

Ahmed Moghieb

Proteins that are differentially expressed or elevated in tissue and biofluids after central nervous system injuries are described. Elevated or reduced levels of the proteins, alone or in various combinations or ratios, can be used to assess severity of central nervous system injury (CNS injury) including traumatic brain injury (TBI), traumatic spinal cord injury (SCI) and chronic traumatic encephalopathy (CTE). Time course measurements post CNS-injury of these proteins can be used to monitor progress or recovery over periods up to several months. Differentiation of acute, subacute and chronic injury can be diagnosed by comparing the protein levels in CNS-injury patients at days 1-3, day 4-10 with levels at day 30-180 in comparison with normal controls.

Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system

Compositions and methods for accurate and sensitive quantitation of T-tau and P-tau are disclosed.

Ultrasensitive assay for tau and methods of use thereof for assessing traumatic brain injury in tissues and biofluids

System is provided for detecting the presence of an analyte of interest in a sample, said system comprising an elongated, transparent container for a sample; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the sample, and wherein the radiation induces a signal which is emitted from the sample; and, at least two linear arrays disposed about the sample holder, each linear array comprising a plurality of optical fibers having a first end and a second end, wherein the first ends of the fibers are disposed along the length of the container and in proximity thereto; the second ends of the fibers of each array are bundled together to form a single end port.

Fiber optical asssembly for fluorescence spectrometry

A system for analyzing a sample for the presence of an analyte in a sample. The system includes a sample holder for containing the sample; an excitation source, such as a laser, and at least one linear array radially disposed about the sample holder. Radiation from the excitation source is directed to the sample, and the radiation induces fluorescent light in the sample. Each linear array includes a plurality of fused silica optical fibers that receive the fluorescent light and transmits a fluorescent light signal from the first end to an optical end port of the linear array. An end port assembly having a photo-detector is optically coupled to the optical end port. The photo-detector detects the fluorescent light signal and converts the fluorescent light signal into an electrical signal.

Fiber optical assembly for fluorescence spectrometry

Hybridoma tumor cell line ATCC No. HB9222. A monoclonal antibody, specific for scrapie-associated fibrils and the proteins which comprise scrapie-associated fibrils, produced by said cell line.

Hybrid cell lines producing monoclonal antibodies dircted against

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Staten Island, NY, United States of America

Richard Rubenstein