Massachusetts Institute of Technology

The Trustees of Boston College

E.i. Dupont De Nemours and Company

The Dow Chemical Company

Zeon Corporation

Univation Technologies, LLC

Univation Technologies, Llc, (us)

Richard Royce Schrock

Amir H Hoveyda

Adam S Hock

Simon J Meek

Annie J King

Yu Zhao

Margaret M Flook

Miao Yu

Ming Joo Koh

Chenbo Wang

Steven J Malcolmson

Benjamin Autenrieth

Robert Baumann

David H McConville

Robert A Dubois

Thach T Nguyen

Robert Toreki

Michael R Reithofer

Jian Yuan

Dmitry Vyacheslavovich Peryshkov

Brian L Goodall

Shigetaka Hayano

Hanmo Zhang

Sebastian Torker

Chaofan Xu

Harold H Fox

Jakub Hyvl

Jonathan Clayton Axtell

Robert V O'Brien

Josep Llaveria Cros

Elizabeth T Kiesewetter

Smaranda C Marinescu

Robert Bauman

John B Alexander

Method of forming a trisubstituted ethylene compound, the method comprising: (A) providing a trisubstituted ethylene compound bearing a first, a second and a third substituent, in which the first and the second substituent are bound to the one olefinic carbon atom and are different from one another; (B) providing a monosubstituted ethylene compound or a disubstituted ethylene compound in which the substituents are vicinally bound to the olefinic carbon atoms, bearing at least a fourth substituent, respectively; (C) subjecting the trisubstituted ethylene compound provided in step (A) to a cross-metathesis reaction with olefin provided in step (B) to form said trisubstituted ethylene, wherein the cross-metathesis reaction is catalysed by a transition metal complex bearing ligands from which one ligand is a carbene ligand, wherein the carbene complex is characterized by a M=C moiety, wherein M is the transition metal; and wherein the reaction proceeds stereoselectively.

Method of preparing trisubstituted ethylene compounds

The present disclosure provides compounds, compositions, and methods for preparing alkenyl halides and/or haloalkyl-substituted olefins with Z-selectivity. The methods are particularly useful for preparing alkenyl fluorides such as CF-substituted olefins by means of cross-metathesis reactions using halogen-containing molybdenum and tungsten complexes.

Halogen-containing metathesis catalysts and methods thereof

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.

Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods

A hydrogenated norbornene-based ring-opening polymer having a syndiotacticity ((racemo diads)/(meso diads+racemo diads)&#xd7;100) of more than 90% is disclosed. A method for producing the same is also disclosed. It is thus possible to provide a hydrogenated highly syndiotactic norbornene-based ring-opening polymer that is formed of a single material, and exhibits high solvent resistance, and a method for producing the same.

Hydrogenated syndiotactic norbornene-based ring-opening polymer

The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.

Highly Z-selective olefin metathesis

The present invention, among other things, provides highly syndiotactic poly(dicyclopentadiene) and/or hydrogenated poly(dicyclopentadiene), compositions thereof, and compounds and methods for preparing the same. In some embodiments, a provided compound is a compound of formula I, II or III. In some embodiments, a provided method comprises providing a compound of formula I, II or III.

Catalysts and methods for ring opening metathesis polymerization

The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and Z-selectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and E-selectivity. In some embodiments, provided technologies are particularly useful for preparing alkenyl fluorides. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-a. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-b.

Metathesis catalysts and methods thereof

The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.

Z-selective ring-closing metathesis reactions

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The present invention provides, among other things, novel compounds and methods for metathesis reactions. In some embodiments, a provided compound has the structure of formula I or II. In some embodiments, the present invention provides compounds and methods for Z-selective olefin metathesis.

The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, a provided compound has the structure of formula I, II or III. In some embodiments, Rof formula I, II or III comprises an electron-withdrawing group. In some embodiments, the present invention provides methods for preparing provided compounds.

The current application describes tungsten oxo alkylidene complexes for olefin metathesis.

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Winchester, MA, United States of America

Richard Royce Schrock