The General Hospital Corporation

Blossom Innovations, LLC

Hypertherm, Inc.

The General Hospital Corporation D/b/a Massachusetts General Hospital

The General Hospital Corporation, Doing Business As Massachusetts General Hospital

The General Hospital Corporation Dba Massachusetts

Blossoms Innovations, LLC

Richard Rox Anderson

William A Farinelli

Dieter Manstein

E Michael Shipulski

Zheng Duan

Jon W Lindsay

Richard W Couch, Jr

Warren M Zapol

Robert H Webb

Joseph Ting

David Jonathan Cook

Stephen M Liebold

Walfre Franco

Joshua Tam

Brian J Currier

Aaron D Brandt

Apostolos G Doukas

Vincent Zuo

Dilip Y Paithankar

Michael R Hamblin

Lilit Garibyan

Guy Best

Henry Hin Lee Chan

Fernanda Hidemi Sakamoto

Peter V Brahan

Martin Purschke

Reginald Birngruber

Ajay Shah

Vincent Hok Liu

Emilia Javorsky

Edward M Shipulski

Luca Zazzeron

Min Yao

Wayne Chin

Matthew M Avram

Mathew Avram

Falguni Asrani

Wikunda Limpiangkanan

Joel N Jimenez-Lozano

Andrea Willey

Kachiu Lee

Oge Onwudiwe

Yakir Levin

Lynn A Drake

Richard Dean Blomgren

Esmeralda Ibarra-silva

Henry Hl Chan

Anna M Yaroslavsky

Sandeep Korupolu

Anna Fischbach

Lynn Drake

Ying Wang

Dilip Paithankar

Hrak Ray Jalian

Henry Hin Chan

Casey Jones

William Farinelli

Exemplary methods and devices can be provided for harvesting a plurality of small tissue pieces, e.g., having widths less than about 1 mm or 0.5 mm, using one or more hollow needles. A fluid can be flowed through a conduit past the proximal ends of the needles to facilitate removal of the tissue pieces from the needle lumens, and can maintain the tissue pieces in a controlled and protective liquid environment. A filter can be used to extract and collect the tissue pieces from the liquid, or the tissue pieces can be deposited directly onto a porous dressing. Such tissue pieces can be used as microscopic grafts, which can be applied directly to a wound site or provided on a substrate or dressing, or stored for later use. Such microscopic grafts can promote tissue regrowth and wound healing, or can be applied to a scaffold to grow new tissue.

Method and apparatus for tissue harvesting

In one aspect, the present invention provides a method of cooling to produce selective disruption of visceral fat tissue in a non-infant human subject comprising infusing a cooled fluid into the abdominal or peritoneal cavity, or into other parts of the body containing visceral fat, to cool the proximal tissue sufficiently to selectively disrupt lipid-rich cells therein, for example, to promote subsequent damage and absorption of lipid-rich cells by the body without producing unwanted effects in non-lipid-rich cells; e.g., without injury to internal organ tissues that could otherwise produce life-threating risks. The cooled fluid can be infused using a catheter arrangement. The cooled fluid can be retained within the abdominal category for a particular duration, and then drained using the catheter arrangement. In certain embodiments, the cooled fluid can be simultaneously introduced into the abdominal cavity and drained therefrom.

Methods and devices for selective disruption of visceral fat by controlled cooling

The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.

Compositions and methods comprising energy absorbing materials for follicular delivery

Systems and methods are provided for performing a hair transplant using a hair transplant device. The hair transplant device comprises an extraction unit including a coring needle configured to extract at least one hair follicle from a donor site, an implanting unit removably coupled to the extraction unit, the implanting unit including a splitting needle configured to create an opening in a recipient site, a housing coupled to the extraction unit, and a user interface extending from the housing and moveable relative to the housing. The user interface includes a pin movable within the coring needle relative to the housing.

Systems and methods for a hair transplant system with extraction and implantation needles

An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

Method and apparatus for selective treatment of biological tissue

Exemplary embodiments of the present disclosure provide method and apparatus for facilitating stretching of a biological tissue by forming a plurality of micro-slits in the tissue. Each micro-slit can be less than about 2 mm or less than about 1.5 mm long, or even less than about 1 mm, such that small gaps that can heal quickly can be formed when the tissue is stretched. The micro-slits can be formed using a plurality of cutting arrangements or an ablative laser. The micro-slits can be formed in various patterns, including staggered rows, circular or spiral patterns, or random patterns.

Method and apparatus for tissue expansion

Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site. The raised (removed) portions of the blisters can be removed and attached to a dressing material, and the portions from the donor (first) site can be placed onto the exposed blister areas at the recipient site.

Method and apparatus for grafting of skin tissue

Systems and methods are provided for locating anatomical features in the skin based on analysis of reflected light, and treating the located anatomical features using high-energy light. A labeling agent can be administered to optically differentiate the anatomical feature.

Systems and methods for selective targeting of structural features in treating skin conditions

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Boston, MA, United States of America

Richard Rox Anderson