Sanofi

Sanofi-aventis

Sanofi-synthelabo

Elf Sanofi

Richard Roux

Georges Garcia

Jean Wagnon

Dino Nisato

Alain Di Malta

Claudine Serradeil-Legal

Claudine Serradeil-Le Gal

Bernard Tonnerre

Gerard Valette

Loic Foulon

Patrick Gautier

Daniel Mettefeu

Marie-Sophie Amiel

Bruno Schoentjes

The invention relates to compounds of formula: and to solvates and/or hydrates thereof, with affinity for and selectivity towards the Vreceptors or both the Vand Vreceptors of arginine-vasopressin. The invention also relates to a process for preparing them, to the intermediate compounds of formula (II) which are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

1,3-dihydro-2H-indol-2-one derivatives, process for preparing them and pharmaceutical compositions containing them

The invention relates to compounds of formula: as well as the possible salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, which have affinity for and selectivity towards the Vreceptors or towards both the Vand Vreceptors of arginine-vasopressin. The invention also relates to the process for preparing them, to the intermediate compounds of formula (II) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for the preparation of medicinal products.

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1,3-dihydro-2H-indol-2one derivatives, process for preparing them and pharmaceutical compositions containing them

The invention relates to compounds of formula:  and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin Vreceptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the Vreceptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

The invention relates to compounds of formula:and to solvates and/or hydrates thereof, with affinity for and selectivity towards the Vreceptors or both the Vand Vreceptors of arginine-vasopressin. The invention also relates to a process for preparing them, to the intermediate compounds of formula (II) which are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

1,3-dihydro-2H-indol-2-one derivatives, method for preparing same and pharmaceutical compositions containing them

1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for V1b and V1a arginine-vasopressin receptors

The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or ocytocin receptors.

1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their

A compound of formula II' ##STR1## in which

Indol-2-one derivatives

1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation

1-benzenesulfonyl-1,3-dihydroindol-2-one derivatives, their preparation

The present invention relates to 1-benzyl-1,3-dihydro-2H-benzimidazol-2-one derivatives, of formula: ##STR1## and to the possible salts thereof, to a process for their preparation and to the pharmaceutical compositions containing them. These compounds have an affinity for the vasopressin and/or oxytocin receptors.

1-benzyl-1,3-dihydro-2H-benzimidazol-2-one derivatives, their

1,3-dihydroindol-2-one derivatives substituted in the 3-position by a

The present invention relates to 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives of the formula: ##STR1## to their preparation and to the pharmaceutical compositions in which they are present. These derivatives have an affinity for the vasopressin and oxytocin receptors.

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Vailhauques, France

Richard Roux