E.i. Dupont De Nemours and Company

Richard R Harris

Neil R Ackerman

Scott E Loveless

Douglas G Batt

Richard S Greenberg

Russell H Neubauer

Russel H Neubauer

4-Quinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing such compounds are useful for the treatment of autoimmune diseases, organ transplantation rejection, graft vs. host disease, multiple sclerosis, and chronic inflammatory diseases such as rheumatoid arthritis.

4-Quinoline carboxylic acid derivatives useful as immunosuppressive

Phenylquinolinecarboxylic acids and derivatives thereof, such as 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, or a sodium or potassium salt thereof, are useful for the treatment of skin and muco-epithelial diseases.

4-quinoline carboxylic acid derivatives useful for treating skin and

Antiinflammatory carbinoloimidazoles are provided which have the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein

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Wilmington, DE, United States of America

Richard R Harris