Neurosolis, Inc.

Wisconsin Alumni Research Foundation

Richard R Copp

Brent D Abraham

James G Farnham

Seth A Hanson

Michael L Hendrickson

Jeffrey C Ockuly

Trevor M Twose

Melinda L Verdone

William E Fahl

Daniel D Peebles

Cynthia E Ochsner

Kathleen L Fahl

The invention relates generally to muscarinic agonists, which are useful for stimulating muscarine receptors, and treating cognitive disorders. Included among the muscarinic agonists disclosed herein are oxadiazole derivatives, compositions, and preparations thereof. Methods of synthesizing oxadiazole compounds also are provided. This disclosure also relates in part to compositions for enhancing cognitive function in subjects such as humans, the compositions comprising a muscarinic agonist or a pharmaceutically suitable form thereof. This disclosure relates in part to methods of treating animals such as humans by administering such compositions.

Cognition enhancing compounds and compositions, methods of making, and methods of treating

Disclosed are muscarinic agonist compounds including oxadiazole derivatives, compositions and preparations thereof. Also disclosed are methods of synthesizing such oxadiazole compounds. Further disclosed are methods for treating a subject with said muscarinic agonists or a pharmaceutically suitable form thereof to enhance cognitive function.

Compounds and compositions for cognition-enhancement, methods of making, and methods of treating

The invention provides novel polyamine compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more chemoprotective polyamines formulated for topical or local delivery to epithelial or mucosal cells are disclosed. Methods of administering the pharmaceutical preparations are also disclosed.

Polyamine compounds and compositions for use in conjunction with cancer therapy

Growing community of inventors

Oregon, WI, United States of America

Richard R Copp