Biosite Diagnostics, Inc.

Other

Becton Dickinson and Company Limited

Biosite Incorporated

Nanogen Recognomics Gmbh

Richard R Anderson

Kenneth Francis Buechler

Gunars E Valkirs

Richard Hugh Anderson

Robert R Anderson

Theodore T Lee

Mark R Nowakowski

Norbert Windhab

John J Carrino

Scott E Castanon

Brian Patrick Dwyer

Stefan Kienle

Jorge Haro

Markus Schweitzer

Michael D Fiechtner

Christoph Brücher

Stefan Raddatz

Bryan G Towns

Roderick A Brownfield

Martin J Bouliane

Jochen Müller

Gregory K Bond

Jill M Orwick

Eberhard Schneider

Marc Pignot

Cassette for a medical device

The present invention relates to conjugates of synthetic binding units and nucleic acids. The present invention also relates to methods for sorting and immobilizing nucleic acids on support materials using such conjugates by specific molecular addressing of the nucleic acids mediated by the synthetic binding systems. Particularly, the present invention also relates to novel methods of utilizing conjugates of synthetic binding units and nucleic acids to in active electronic array systems to produce novel array constructs from the conjugates, and the use of such constructs in various nucleic acid assay formats. In addition, the present invention relates to various novel forms of such conjugates, improved methods of making solid phase synthesized conjugates, and improved methods of conjugating pre-synthesized synthetic binding units and nucleic acids. The present invention also relates to the use of conjugates of synthetic binding units and nucleic acids as substrates for various enzymatic reactions, including nucleic acid amplification reactions.

Enzymatic modification of a nucleic acid-synthetic binding unit conjugate

Assay for detecting the amount or presence of target ligand in a sample. The assay includes a ligand analogue conjugate having a linkage site and a binding site, a ligand receptor, and a sample. The assay includes the steps of providing at least one crosstalk inhibitor. This inhibitor, under assay conditions, competes with the linkage site of the ligand analogue conjugate for binding to the ligand receptor, and does not compete with the binding site of the ligand analogue conjugate for binding to the ligand receptor. In the invention, the assay is performed for the target ligand in the presence of a sufficient amount of the crosstalk inhibitor to reduce the amount of binding of the linkage site of the ligand analogue conjugate to the ligand receptor. The invention also features a method for identifying crosstalk inhibitors, and the crosstalk inhibitors themselves.

Crosstalk inhibitors and their uses

A cubicle door is comprised of first and second brackets for wrapping over the top edges of a cubicle panel on opposite sides of the entry way. A roller blind has a proxiinal end hinged to the first bracket, and a distal end which is removably supported on a support attached to the second bracket. The end of the roller blind is received in either one of perpendicular grooves on top of the support. The grooves allow the roller blind to meet the second support at different fixed angles to fit the shape of the entry way. Alternatively, a rotatable turret with a notch is arranged on the second bracket. The roller blind is received in the notch, and the second bracket may be oriented at different angles relative to the roller blind by rotating the turret.

Cubicle door

Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network

Assay methods for performing non-competitive ligand-receptor assays, where said assays provide a sensible result when the target ligand identified by the assay is present at a concentration greater than a defined threshold concentration. The threshold concentration can be selected to be the upper limit of a normal range of values for a target ligand in a sample, so that an assay in accordance with the invention provides a sensible result only when the target ligand is present at elevated levels.

Non-competitive threshold ligand-receptor assays

Devices for use in heterogeneous ligand-receptor assays, having a porous member in contact with a nonabsorbent textured surface, where the surface texturing is such that a capillary network is formed when in fluid communication with the porous member. More particularly, these devices comprise:

Assay devices comprising a porous capture membrane in fluid-withdrawing

This invention is directed to a ligand-receptor assay for determining the presence of at least one target ligand, capable of competing with a ligand analogue conjugate for binding sites available on a ligand receptor, said ligand analogue conjugate comprising at least one ligand analogue coupled to a colloidal gold particle, in a fluid sample suspected of containing said target ligand comprising the steps of:

Threshold ligand-receptor assay

The present invention comprises a hollow globe including a plurality of apertures which are formed substantially throughout the entire surface of the globe. Formed within the globe and disposed in laminar juxtaposition to the interior surface of the globe's sphere, a bladder means is formed of an opaque flexible material. A plurality of cross slits are formed on the bladder in substantial alignment with the globe's surface. An internal light source is disposed within said bladder at approximately the midpoint of the globe's sphere, and a plurality of luminescent pegs are provided for insertion into the apertures formed in the globe's surface. The present invention provides the user with the plurality of luminescent, differently colored pegs to design a picture or art form. The present invention may additionally serve as a night light and the luminescent pegs may be specially adapted to project light from the interior of the globe's surface to the exterior of the globe and onto surrounding walls and ceilings. The globe may additionally be rotatable around the axis by a rotating mechanism which is controlled by an on/off switch.

Spherical construction toy and light apparatus

A drawing template for facilitating the formation of images upon a spherical surface is disclosed. In a first embodiment the template comprises first and second transparent hollow hemispheres having indicia formed upon their surfaces such that the two hemispheres may be disposed about a spherical drawing surface and the indicia may then be used as a guide to form corresponding images upon the drawing surface. In a second embodiment, a planar sheet of flexible material is configured such that it will conform substantially to the shape of a sphere when placed in laminar juxtaposition therewith. Indicia formed upon the sheet of flexible material provide a guide by which images may be formed upon the drawing surface. Both embodiments of the drawing template of the present invention are particularly applicable for use with a three-dimensional drawing device which forms images upon the inner surface of a transparent sphere.

Spherical drawing template

This invention is directed to a ligand-receptor assay for determining the presence or amount of at least one target ligand, capable of competing with a ligand analogue conjugate for binding sites available on a ligand receptor, said ligand analogue conjugate comprising at least one ligand analogue coupled to a signal development element capable of emitting a detectable signal, in a fluid sample suspected of containing said target ligand, comprising the steps of:

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Encinitas, CA, United States of America

Richard R Anderson