Advanced Aesthetic Technologies, Inc.

Cbm Intellectual Properties, Inc.

Cbm Intellectural Properties, Inc.

Advanced Aesthetic Techmologies, Inc.

Fmc Corporation

Richard Provonchee

Leonard B Miller

Valentino Gitto

Samuel Nochumson

Francis H Kirkpatrick

Mary S Riley

Richard Burtt

Narendra Vartak

Kenneth Guiseley

Agaroid structures in the form of an agaroid matrix, a sintered agaroid, or an agaroid mat are disclosed which may, in some embodiments, include a chemically crosslinked agaroid, a derivatized agaroid, and/or an agaroid coupled with one or more ligands. The agaroid structures may be formed by precipitation from a glycol solution, in some cases, and may be converted to be insoluble in water below 40C. In another aspect, methods of treating a condition of a mammal are disclosed, which include contacting an area of a mammalian body with a composition having an agaroid structure with or without one or more beneficial agents. In yet another aspect, the present disclosure provides methods of filling or bulking tissue in a mammalian body by implanting a converted agaroid composition into the mammalian body, which may include converted agaroid microbeads and/or converted agaroid particles.

Agaroid structures and related methods of use and manufacture

Hydrogel fracturing devices are described herein that include a chamber with an inlet, outlet, and at least one fracturing structure which extends across the entire internal diameter of the chamber. The fracturing structure includes one or more apertures or screens. The fracturing device may be connected to a syringe and/or ampoule containing a hydrogel formulation. The hydrogel formulation may then be fractured by forcing the formulation through the fracturing device.

Methods and devices for fracturing a hydrogel prior to delivery through a needle

Provided herein are therapeutic and cosmetic methods that utilize an in situ gelling agaroid composition in the form of a water reactive agaroid. The composition described herein is applicable in the fields of wound healing, tissue bulking, bone grafting, and drug delivery.

Agaroid compositions and methods of use thereof

Methods of forming cross-linked polysaccharides are disclosed in which one or more polysaccharides are dissolved in solution, gelled, modified to have a desired concentration, and subsequently irradiated. The irradiation of the gel crosslinks the polysaccharide(s) present. The disclosed techniques may be applied to various polysaccharides, including but not limited to agarose and/or hyaluronic acid.

Crosslinked polysaccharides and related methods

Irradiated agarose gels and compositions containing irradiated agarose gels are described, along with methods of production and use. Methods of forming an irradiated agarose composition include irradiating an agarose in dry form to produce an irradiated agarose, dissolving the irradiated agarose in a solvent to form a solution containing irradiated agarose, and gelling the solution containing irradiated agarose to form a gel containing irradiated agarose. The resulting gel containing irradiated agarose may have a reduced gel strength, making it more suitable for use as an injectable, even at high concentrations.

Irradiated agarose, compositions thereof, and related methods

Dermal filling materials and techniques are disclosed herein. In particular, dermal fillers containing low melt agarose (i.e., agarose having a melting temperature of less than 65&#xb0; C.) are described. The disclosed dermal fillers can be manipulated after injection by, for example, heating and/or cooling the dermal filler while inside the patient to adjust its positioning or stiffness.

Low melt temperature agarose for dermal filling and related applications and methods

A packaging arrangement is disclosed for protecting an electrophoresis gel from damage during shipment and storage. The package arrangement includes first and second sheets that are sealed about their respective edges to form an enclosed cavity. The cavity is at least partially evacuated of air. An electrophoresis gel is located within the cavity. A support sheet may be disposed between the electrophoresis gel and the package to facilitate removal of the gel and to further stiffen the package. In one embodiment of the invention, a plurality of electrophoresis gels are disposed within the cavity. Each gel is preferably separated from adjacent gels by a spacer. In another embodiment of the invention, the gel is disposed within a tray which, in turn, is located within the cavity.

Package for electrophoresis gels

A gel running plate for use in an electrophoresis process to cover an electrophoresis gel positioned within a tray. The gel running plate adapted to effect flow of electrical current into and out of the tray. The gel running plate having a length less than a length of the tray such that a gap exists between the tray and the plate when the plate is positioned on the tray. The gel running plate also having a width at least as wide as the width of the tray such that the plate rests upon the tray when the plate is positioned on the tray.

Growing community of inventors

Cushing, ME, United States of America

Richard Provonchee