Northwestern University

Akzo Nobel N.v.

Richard P Van Duyne

Mark C Hersam

Joseph T Walsh, Jr

Olga Lyandres

Jonathan M Yuen

Anne-Isabelle Henry

Nilam C Shah

Timothy P Tyler

Jeffrey W Elam

Ralph Franklin

William J Parr

Peter C Stair

Anthony J Castro

Michael J Natan

Christy Lynn Haynes

Matthew R Glucksberg

Mathew R Glucksberg

George C Schatz

Matthew Young

Karen E Peltier

Chanda Ranjit Yonzon

Douglas A Stuart

Xiaoyu Zhang

Jing Zhao

King C Sheng

Alyson V Whitney

Robert J Bianchini

Shengli Zou

A sensing platform includes a substrate, an array of wells formed in the substrate, and sorted nanoparticles filling in the array of wells such that each well contains a single sorted nanoparticle, wherein the sorted nanoparticles are in a cluster state.

Sorting process of nanoparticles and applications of same

The present invention provides systems and methods employing a surface enhanced Raman biosensor and sensing devices for collecting spatially offset Raman spectra from the biosensor. In certain embodiments, the present invention provides systems and methods for quantifying the concentration of an analyte in a subject, and/or identifying the presence or absence of an analyte in a subject, from a plurality of spatially offset Raman spectra generated from a surface enhanced Raman biosensor implanted in a subject.

Combined surface enhanced and spatially offset Raman spectroscopy for biomolecule detection

In one aspect of the present invention, a method for sorting nanoparticles includes preparing a high-viscosity density gradient medium filled in a container, dispersing nanoparticles into an aqueous solution to form a suspension of the nanoparticles, each nanoparticle having one or more cores and a shell encapsulating the one or more cores, layering the suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container, and centrifugating the layered suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container at a predetermined speed for a predetermined period of time to form a gradient of fractions of the nanoparticles along the container, where each fraction comprises nanoparticles in a respective one of aggregation states of the nanoparticles.

The present invention relates to compositions, devices and methods for detecting microorganisms (e.g., anthrax). In particular, the present invention provides portable, surface-enhanced Raman biosensors, and associated substrates, and methods of using the same, for use in rapidly detecting and identifying microorganisms (e.g., anthrax).

Compositions, devices and methods for SERS and LSPR

The present invention relates to biosensors, in particular to surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides compositions and methods for the in vivo detection of analytes such as glucose.

Surface-enhanced raman nanobiosensor

A method for providing a conductive metal deposit on the surface of a dielectric substrate by applying a composition comprising a mixture of a salt and amine or amide compound to the substrate and subjecting the composition to a continuous wavelength laser beam.

Laser direct writing

Growing community of inventors

Wilmette, IL, United States of America

Richard P Van Duyne