Eli Lilly and Company

Richard P Pioch

John M Schaus

Kenneth S Hirsch

Leander Merritt

Robert D Titus

Klaus K Schmiegel

James Arthur Nixon

This invention provides ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes which are selective inhibitors of serotonin reuptake.

Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes

N-alkyl-N'-(2-aminomethyl-4-thiazolylmethylthio)alkyl guanidines, thioureas, ethenediamines and related compounds, H.sub.2 -receptor antagonists, useful in inhibiting gastric acid secretion in mammals.

N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds

N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds

This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain imidazole derivatives. Pharmaceutical formulations of the imidazole derivatives and certain imidazoles are also provided.

Aromastase inhibiting

N-alkenyl (or N-alkynyl)-N'-[2-(aminoalkyl)-4-thiazolylmethylthio]alkylguanidines, thioureas, ethenediamines and related compounds, H.sub.2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.

N-Thiazolylmethylthioalkyl-N.sup.1 -alkenyl (or alkynyl)guanidines and

2-[2-(2-aminoalkyl-4-thiazolylmethylthio)-alkylene]amino-5-aromatic-substit uted alkylene-4-pyrimidones and related compounds, H.sub.2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.

2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyr

N-alkyl-N'-(2-aminoalkyl-4-thiazolylmethylthio)alkyl guanidines, thioureas, ethenediamines and related compounds, H.sub.2 -receptor antagonists, useful in inhibiting gastric acid secretion in mammals.

N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds

N-Alkyl-N'-([2-(aminoalkyl)-4-thiazolylmethyl]thioalkyl) guanidines, thioureas, ethenediamines and related compounds, H.sub.2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.

N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl

3-(Imidazol-4-yl)-2-phenylpropanenitriles are useful for control of powdery mildew of cultivated plants.

3-(Imidazol-4-yl)-2-phenylpropanenitriles

A series of 5-halo-4-oxo-2-phenylpentanenitriles are useful as intermediates for preparing 3-(imidazol-4-yl)-2-phenylpropanenitriles, which are useful as fungicides.

5-Halo-4-oxo-2-phenylpentanenitriles

3-Phenacylpiperidines, useful as depressants, stimulants, and anti-inflammatory agents, are obtained by preparing, from a 3-halomethylpiperidine, a 3-piperidylmethylmagnesium halide which is condensed with a benzonitrile.

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Indianapolis, IN, United States of America

Richard P Pioch