Genetics Institute, Inc.

Richard P Northey, Jr

Brian D Kelley

C Michael Philbrook

Jay A Schrier

Michael C Huberty

Kalvin W Yim

Jane S Tjia

A formulation is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein and a sponge of porous particulate polymer matrix. The sponge may be prepared by treating the porous particulate polymer matrix with a suitable fusing material such as ethanol and a surfactant such as a polysorbate.

Formulations for delivery of osteogenic proteins

A composition is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein; a porous particulate polymer matrix; an osteogenic protein-sequestering amount of blood clot; and a calcium sulfate hemihydrate-containing substance. Also disclosed are formulations of bone morphogenetic proteins with improved solubility and/or stability characteristics.

Growing community of inventors

Ipswich, MA, United States of America

Richard P Northey, Jr