University of Utah Research Foundation

Institut National De La Sante Et De La Recherche Medicale

The Brigham and Women's Hospital, Inc.

Richard P Lifton

Jean-Marc Lalouel

Xavier Jeunemaitre

Youri Kotelevtsev

Pierre Corvol

Florent Soubrier

Pierre Corval

Florant Soubrier

The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.

Method to determine predisposition to hypertension

The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood pressure.

The association of molecular variants of the angiotensinogen gene with human essential hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.

Angiotensinogen gene variants and predisposition to hypertension

A method of screening for glucocorticoid remediable aldosteronism (GRA) in a mammal by detecting the presence or absence of a chimaeric gene duplication resulting from unequal crossing over of the 11, .beta.-hydroxylase and aldosterone synthase genes, or the product encoded by the chimaeric gene duplication. Presence of the chimaeric gene duplication or its encoded product is indicative of a mammal afflicted with GRA and absence of the chimaeric gene duplication or its product is indicative of a mammal not afflicted with GRA.

Direct genetic test for glucocorticoid-remediable aldosteronism

The association of molecular variants of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.

Growing community of inventors

Guilford, CT, United States of America

Richard P Lifton