Becton Dickinson and Company Limited

City University of New York

Richard P Clarke

Frank E Martin

M Ishaq Haider

George R Titus

Richard Klug

Noel G Harvey

Susan L Burkett

Yelena G Tropsha

David Alan Martin

Bryan Soo Wong

Jess M Waller

Donald N Payne, Jr

O Elmo Millner

Weston F Harding

Andrew B Auerbach

Alexander George Lastovich

John A Mikszta

Jason B Alarcon

John P Dekker, Iii

Bhanu P S Chauhan

Mitchell K Antoon

Yelena G Trophsa

M Lehag Haider

Umar Latif

James K Fentress

John P Iii Dekker

Ishaq M Haider

A system and method is provided for an injectable substance delivery device comprising a limiter, shoulder or post that controls how deep the needle is inserted into the tissue. The limiter is sized in proportions that control the maximum insertion depth of the needle into the tissue without excessively restricting the complete insertion of the needle. The system and method further comprises an normalization or stabilizer ring that prevents distortion of the tissue in the vicinity of the infusion, so that the needle length is the major determining factor as to how deep the infusion is delivered.

Intradermal delivery device

A system and method is provided for an injectable substance delivery device comprising a limiter, shoulder or post, that controls how deep the needle is inserted into the tissue. The limiter is sized in proportions that control the maximum insertion depth of the needle into the tissue without excessively restricting the complete insertion of the needle. The system and method further comprises an normalization or stabilizer ring that prevents distortion of the tissue in the vicinity of the infusion, so that the needle length is the major determining factor as to how deep the infusion is delivered.

The present invention provides multi-arm siloxane-based molecules suitable for use as a drug delivery vehicle comprising a central core molecule that comprises a cyclic or cubic siloxane, and a plurality of arms attached to the central core molecule, wherein each arm comprises an organic moiety. The multi-arm siloxane-based molecules described herein are suitable for encapsulation of a therapeutic agent. The invention further includes pharmaceutical compositions comprising the claimed multi-arm siloxane-based molecules and an encapsulated therapeutic agent in combination with a pharmaceutically acceptable carrier. Methods of making and using the multi-arm siloxane-based molecules are also provided.

Multi-arm cyclic or cubic siloxane-based formulations for drug delivery

An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.

Microabrader with controlled abrasion features

The present invention is a plastic container coated with a multi-layer barrier coating. The multi-layer barrier coating is useful for providing an effective barrier against gas permeability in containers and for extending shelf-life of containers, especially plastic evacuated blood collection devices.

Blood collection tube assembly

The present invention is a plastic container coated with a barrier coating. The barrier coating is useful for providing an effective barrier against gas permeability in containers and for extending shelf-life of containers, especially plastic evacuated blood collection devices.

Barrier coating

A lubricious polymeric composition which is stable toward sterilizing radiation includes a semicrystalline polyolefin of narrow molecular weight distribution having incorporated therein a liquid mobilizing additive, a radiation stabilizing amount of a hindered amine, a lubricating amount of an erucic acid derivative and a clarifying amount of a sorbitol derivative. The invention includes a sterilized article fabricated from the composition and a method to radiation sterilize the article.

Lubricious radiation stable polymeric composition and method for

Lubricious radiation stable polymeric composition and articles therefrom

Dibenzylidene xylonates are a new class of clarifiers for polyolefins. The invention includes polyolefin compositions having the new clarifiers therein.

Clarifiers for polyolefins and polyolefin compositions containing same

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Raleigh, NC, United States of America

Richard P Clarke