Smithkline Beecham Corporation

Other

Affinium Pharmaceuticals, Inc.

The Brigham and Women's Hospital, Inc.

Virus Research Institute

Richard Oakley Nicholas

John Edward Hodgson

Michael Terence Black

Michael Arthur Lonetto

Julie M Pratt

Martin M Rosenberg

Judith M Ward

David Justin Charles Knowles

Raymond Winfield Reichard

David Justin Knowles

Leslie Marie Palmer

Robert King Stodola

Patrick Vernon Warren

Martin Karl Russel Burnham

Richard Lloyd Warren

Martin Karl Burnham

Jason Craig Fedon

Elizabeth Jane Lawlor

Christopher Michael Traini

Andrew P Fosberry

Anna Lisa Kosmatka

John E Hodgson

Min Wang

Deborah Dee Jaworski

Lisa Kathleen Shilling

Martin Karl Russell Burnham

Robert L Deresiewicz

Adrian M Lowe

David T Beattie

Christine Marie Debouck

Jeffrey L Mooney

James Raymond Brown

Magdalena Zalacain

David John Holmes

Yi Yi Zhong

Phillip N Zarfos

Rebecca Claire Greenwood

Robert H Reid

Nicola Gail Wallis

George P Livi

Michael Terance Black

Jamie M Pratt

Raymond Winfield Riechard

Robert H Reid, Jr

Simon J Foster

Kathryn Belinda Freeman

Yi Y Zhong

This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Compounds

The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.

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The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.

The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.

Member of ATP dependent protease family, clpL

The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.

ribB

The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Prokaryotic polynucleotides polypeptides and their uses

The invention provides ARO1 polypeptides and DNA (RNA) encoding such ARO1 and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such ARO1 for the treatment of infection, particularly fungal infections. Antagonists against such ARO1 and their use as a therapeutic to treat infections, particularly fungal infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of ARO1 nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding arom and for detecting the polypeptide in a host.

ARO1 multifunctional polypeptide of Candida albicans

The invention provides Glutamine Transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Glutamine Transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glutamine Transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.

Polynucleotides encoding a novel glutamine transport ATP-binding protein

The invention provides pai polypeptides and DNA (RNA) encoding pai polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pai polypeptides to screen for antibacterial compounds.

The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.

ribG

The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for antibacterial compounds.

PhoH homolog

The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.

GbpA

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Collegeville, PA, United States of America

Richard Oakley Nicholas