Medtronic, Inc.

Cardiac Pacemakers, Inc.

Richard N Cornelussen

Berthold Stegemann

Frits W Prinzen

Joseph M Pastore

Ward Y R Vanagt

Robert W Stadler

Tamara Colette Baynham

Julio Cesar Spinelli

Andrew P Kramer

Allan Charles Shuros

Jihong Qu

Subham Ghosh

Lilian Kornet

Ward Y Vanagt

Richard J O'Brien

Raphael Schneider

Alfonso Aranda Hernandez

Robert Vestberg

Mirko De Melis

Richard Sutton

Asimina Glynou

Pascalle Reiters

Ulrich Wolfhard

Joeri Heynens

Jeffrey M Gillberg

Mark T Marshall

Troy Edward Jackson

Thomas A Anderson

Teresa A Whitman

Richard P M Houben

Antoine N Camps

Jean J Rutten

Carla Pfeiffer

Paul Adams

Ralph Leinders

Ward YR Vanagt

Ward Vanagt

Frits Prinzen

In some examples, a system can be used for delivering cardiac resynchronization therapy (CRT). The system may include a pacing device configured to be implanted within a patient. The pacing device can include a plurality of electrodes, signal generation circuitry configured to deliver ventricular pacing via the plurality of electrodes, and a sensor configured to produce a signal that indicates mechanical activity of the heart. Processing circuitry can be configured to identify one or more features of a cardiac contraction within the signal, and determine whether the contraction was a fusion beat based on the one or more features.

Adaptive cardiac resynchronization therapy

In some examples, determining a heart failure status using a medical device comprising one or more sensors includes determining a first value of a heart beat variability metric of a patient while an activity state of a patient satisfies an inactivity criterion based on a signal received from the one or more sensors, and determining, within a predetermined period of time after further determining that the activity state of the patient no longer satisfies the inactivity criterion, a second value of the heart beat variability metric while the activity state of the patient no longer satisfies the inactivity criterion based on the signal. A difference between the first value of the heart beat variability metric and the second value of the heart beat variability metric may be determined and the heart failure status of the patient may be determined based on the difference.

Sensing for heart failure management

Cardiac resynchronization therapy diagnostics

A medical system including processing circuitry configured to receive a cardiac signal indicative of a cardiac characteristic of a patient from sensing circuitry and configured to receive a glucose signal indicative of a glucose level of the patient. The processing circuitry is configured to formulate a training data set including one or more training input vectors using the cardiac signal and one or more training output vectors using the glucose signal. The processing circuitry is configured to train a machine learning algorithm using the formulated training data set. The processing circuitry is configured to receive a current cardiac signal from the patient and determine a representative glucose level using the current cardiac signal and the trained machine learning algorithm.

Self-calibrating glucose monitor

An implantable device and associated method for delivering multi-site pacing therapy is disclosed. The device comprises a set of electrodes including a first and second left ventricular electrodes spatially separated from one another and a right ventricular electrode, all coupled to an implantable pulse generator. The processing circuit coupled to the implantable pulse generator, the processing circuit configured to determine whether a prospective heart failure condition has occurred and if so to trigger the pulse generator to switch from a first pacing mode to a second pacing mode, the first pacing mode comprising delivering only a first pacing pulse to a left ventricle (LV) and thereafter delivering an RV pacing pulse to the right ventricular electrode within a single cardiac cycle and the second pacing mode comprising delivering first and a second pacing pulses to the LV and thereafter delivering an RV pacing pulse to the right ventricular electrode within a single cardiac cycle.

Efficient delivery of multi-site pacing

Devices and methods are described herein for treating cardiac conditions using electrical stimulation delivered to and sensing nerve activity from one or both of the AV node and nerve tissue innervating the AV node using one or more neural electrodes positioned in a location within the triangle of Koch of the right atrium.

Atrioventricular nodal stimulation

Systems and methods may monitor electrical activity of a patient's heart using electrodes during delivery of cardiac conduction system pacing therapy, generate electrical heterogeneity information (EHI) based on the monitored electrical activity during delivery of cardiac conduction system pacing therapy, and determine whether the cardiac conduction system pacing therapy would benefit from supplemental cardiac pacing therapy based on the generated EHI.

Supplementation of cardiac conduction system pacing therapy

The invention relates to a prosthetic valve () for regulating fluid flow between an upstream side () and a downstream side () and being operable between an open status and a closed status. The prosthetic valve comprises: &#x2014;an orifice () arranged in a surrounding member () and extending between the upstream side () and the downstream side () wherein in the open status of the prosthetic valve () the fluid flow through the orifice is maximally enabled and wherein in the closed status of the prosthetic valve the fluid flow through the orifice in a restriction direction () from the downstream side () to the upstream side () is restricted; and&#x2014;a leaflet () arranged in the orifice and being operable between an open status corresponding to the open status of the prosthetic valve and a closed status corresponding to the closed status of the prosthetic valve. The prosthetic valve further comprises regurgitation means () arranged in the prosthetic valve for achieving regurgitation in the restriction direction and arranged for becoming ineffective after a period of deployment.

Prosthetic valve for regulating fluid flow

A method includes determining that a patient has heart failure with preserved ejection fraction (HFpEF); configuring a cardiovascular (CV) model using patient characterization data; determining one or more therapy parameters using output data of the CV model; and administering HFpEF therapy based on the one or more therapy parameters.

Model-based therapy parameters for heart failure

In some examples, a system may be used for delivering cardiac therapy or cardiac sensing. The system may include an in implantable medical device including a housing configured to be implanted on or within a heart of a patient, a fixation element configured to attach the housing to the heart; and a sensor configured to produce a signal that indicates motion of the implantable medical device. Processing circuitry may be configured to identify one or more impingements between the housing and another structure, such as a tissue of the heart, based on the signal from the sensor and provide an indication of the one or more impingements to a user.

Impingement detection for implantable medical devices

In some examples, an implantable medical device (IMD) that includes a pulse generator comprising a housing, electrodes, and circuitry configured to deliver cardiac pacing via the electrodes. The IMD may further include a lead including at least one of the electrodes, an elongate body, a fixation helix, and a connector segment. A width of the helix transverse to a longitudinal axis of the lead is greatest at a distal end of the helix. A proximal end of the elongate body may be connected to a distal end of the pulse generator, and the helix may be attached to a distal end of the elongate body. The pulse generator may include a first connector tab. A distal end of the connector segment may be configured to receive the proximal end of the elongate body and a proximal end of the connector segment may include at least one second connector member configured to engage the first connector tab.

Leaded electrical stimulation system

Growing community of inventors

Eijsden, Netherlands

Richard N Cornelussen