Health Research, Inc.

Richard Mazurchuk

Ravindra Kumar Pandey

Peter Kanter

Lalit Goswami

Youcef M Rustum

Arup Bhattacharya

Joseph A Spernyak

Karoly Toth

Harry K Slocum

Rami G Azrak

Sreenivasulu Chintala

Mukund Seshadri

Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in macular degeneration. Broadly, the compounds are tetrapyrollic photosensitizer compounds where the tetrapyrollic compound is a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide having 3 to 6 &#x2014;CHCONHphenylCHCH(N(CHCOOH)))(CHN(CHCOOH)(CHCHN(CHCOOH))) groups or esters thereof or complexes thereof with gadolinium(III).

Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents

This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.

Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium

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Clarence Center, NY, United States of America

Richard Mazurchuk