University of South Florida

Medicines for Malaria Venture

The United States Government As Represented by the Department of Veterans Affairs

Oregon Health & Science University

Richard Matthew Cross

Dennis Edward Kyle

Roman Manetsch

Rolf W Winter

Michael Kevin Riscoe

David J Hinrichs

Jane Xu Kelly

Aaron Nilsen

Martin J Smilkstein

David Lawrence Flanigan

Jeremy Burrows

Andrii Monastyrskyi

Niranjan Kumar Namelikonda

Jordany Richarlson Maignan

Alexis Nichole LaCrue

Tina Susanna Mutka

Fabian Ernesto Saenz

Compounds having antiparasitic or anti-infectious activity

Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of ainfection in the recipient subject, or to reduce the likelihood of the onset or establishment of ainfection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.

4(1H)-quinolones having antimalarial activity with reduced chemical resistance

Growing community of inventors

Brandon, FL, United States of America

Richard Matthew Cross