Montefiore Medical Center

Richard M LoPachin

Terrence Gavin

Brian Geohagen

Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.

Multifunctional cytoprotectant for treatment of pathogenic processes mediated by oxidative stress and toxic electrophiles

Methods and compositions using 1,3-dicarbonyl compounds are disclosed for treating toxicity due to therapeutic agents and agents that causes oxidative cellular damage and for treating liver ischemia-reperfusion injury, as well as diseases and disorders that are improved through administration of N-acetylcysteine.

Methods and compositions for preventing and treating electrophile-mediated toxicities

Methods and compositions are disclosed for treating a subject with a disease or tissue injury mediated by cellular oxidative stress or with an environmental toxicity due to an electrophilic toxicant or pollutant, and for providing a nutritional supplement to a subject and for providing a skin treatment for a subject, where the methods comprise administering to the subject a 1,3-dicarbonyl compound.

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New Rochelle, NY, United States of America

Richard M LoPachin