Australian Nuclear Science and Technology Organisation

Australian Nuclear Science and Technology Organization

Richard M Lambrecht

Suzanne V Smith

Fook-Thean Lee

Peter F Schmidt

Nadine M Di Bartolo

Timothy W Jackson

Masaharu Kojima

Therese M Donlevy

A physiologically acceptable, radiolabelled compound of general formula (I) consisting of a compound of the ##STR1## where k is an integer from 2 to 5 l is an integer from 1 to 5 X and Y are independently selected from phenyl, naphthyl, pyridine or quinoline radical, each having at position 2 one of --OH, --SH, --NH.sub.2 or --COOH and each of X and Y can be optionally substituted by one or more amino, halogen, hydroxy, mercapto, nitro, cyano, thiocyano, alkyl, alkoxy, halogenoalkyl, acyl, acylamino, acyloxy, carboxyl, alkoxycarbonyl, carbamoyl, pyridoylamino, N-carboxyalkyl-carbamoyl, sulpho, sulphamoyl, mono- or dialkylated or phenylated sulphamoyl which can also carry one or more substituents R', alkylsulphonyl, alkoxysulphonyl, or by an optionally hydroxy-containing phenylsulphonyl or phenoxysulphonyl; where R' is as defined for X and Y; or pharmaceutically acceptable salts thereof.

Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating

A physiologically acceptable, radiolabelled compound of general formula ##STR1## where k is an integer from 2 to 5

Rhenium complexes of formula (I), radiolabelled complexes thereof or pharmaceutically acceptable salts thereof: ##STR1## wherein R is straight or branched chain C.sub.1-10 alkyl, C.sub.1-10 alkenyl, C.sub.1-10 alkynyl optionally substituted by cycloalkyl or aryl; C.sub.1-10 cycloalkyl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or aryl; or aryl optionally substituted by straight or branched chain alkyl, alkenyl, alkynyl or cycloalkyl for use in liver cancer therapy and metastasis of cancer.

Rhenium complexes

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Birchgrove, Australia

Richard M Lambrecht