Baxter International Inc.

Zymogenetics, Inc.

Mallinckrodt Pharma IP Trading D.a.c.

Richard M Garcia

Paul D Bishop

Steven D Hughes

Gerald W Lasser

Richard I Senderoff

Jeffrey D Meyer

Emily N Rollins

Katherine E Lewis

Penny Thompson

Paul O Sheppard

Robert R West

Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked gelatin microspheres with pores. In another embodiment, the hemostatic composition comprises an additive such as a wetting agent, a suspending agent, or both. The hemostatic compositions may also include a hemostatic agent such as thrombin, and may include a high concentration of thrombin. The hemostatic compositions may also include plasma. Also provided herein are devices for dispersing said hemostatic compositions in a diluent, and delivering said dispersed hemostatic composition. The hemostatic compositions may also fabricated with a selected geometry as administration suggests.

Hemostatic microspheres

The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.

Methods of modulating gastrointestinal contractility

Uses of human Zven proteins and polynucleotides

Growing community of inventors

Kirkland, WA, United States of America

Richard M Garcia