University of Texas System

The Texas A&m University System

Sandia Corporation

Richard M Crooks

Antonio J Ricco

Hong Liu

Li Sun

Long Luo

Mona Wells

Christophe Renault

Yi-Ju Tsai

Josephine Hofstetter

Jonathan K Schoer

Kwok-Chu Chan

Ian Richards

Molly Kogan

Karen Scida

Taisun Kim

Provided herein are methods and devices for the detection of analytes. The methods employ particles formed from a first metal conjugated to analytes. The analyte conjugated to the particle formed from the first metal can be accumulated at a working electrode. The first metal can be galvanically exchanged with ions of a second metal to form a layer of the first metal at the working electrode. The first metal can then be electrochemically detected and/or quantified. Using this method, analytes can be detected at low concentrations a few femtomolar via anodic stripping voltammetry, with no washing steps or electrode modifications.

Methods and systems for the detection of analytes

Described herein are three-dimensional (3-D) paper fluidic devices. The entire 3-D device is fabricated on a support layer formed from a single sheet of material and assembled by folding the support layer. The folded structure may be enclosed in an impermeable cover or package. Chemically sensitive particles may be disposed in the support layer for use in detecting analytes.

Method for the detection and quantification of analytes using three-dimensional paper-based devices

According to one embodiment an apparatus includes a membrane and at least a portion of a nanotube imbedded within the membrane. The portion of the nanotube imbedded within the membrane provides a conduit through the membrane.

Method and apparatus for nanoparticle transport and detection

A substrate having a dendrimer monolayer film thereon is provided. The film can comprise either dendrimers, or dendrons (dendrimer branches). In each case, the monolayer films are covalently bonded to the desired surface. The resulting structure can be employed in a variety of applications including chemical sensors.

Dendrimer monolayer films

A self-assembled multilayer and in particular polymeric self-assembled multilayer can be effectively produced from two or more self-assembled monolayers on a substrate where each of the self-assembled monolayers is produced for a block containing a first functional group and a second functional group where the second functional group is reacted with the first functional group. The production of polymerizable, self-assembled mono- and multi-layers from, e.g., blocks containing at least two acetylene groups and/or polymerizable end groups, is also provided. The polymerized mono- or multilayer can be employed in a variety of applications including photolithography.

Polymeric self-assembled mono- and multilayers and their use in

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College Station, TX, United States of America

Richard M Crooks