Rutgers, The State University of New Jersey

Richard Lutz

Paul G Falkowski

Eileen White

Liti Haramaty

Eric Andrianasolo

Eric H Andrianasolo

The invention provides a compound of formula (I): (I) wherein R-Rhave any of the values defined in the specification, as well as compositions comprising a compound of formula (I) and methods for treating diseases (e.g. cancer). 

Ceramide derivatives as anticancer agents

Compounds of formulas I-IV: (I), (II), (III) (IV), wherein: Rand R-Rare independently selected from H and 1-3 carbon lower alkyl; and Rand Rare independently selected from H, 1-3 carbon lower O II alkyl, and &#x2014;C&#x2014;R, wherein Ris 1-3 carbon lower alkyl. Pharmaceutical compositions, which include any of Compounds I-IV and a pharmaceutically acceptable carrier, methods of inducing tumor cell apoptosis by administering to a patient in need thereof an effective amount of any of Compounds I-IV, and methods for obtaining any of Compounds I-IV by extracting the compound from coral are also provided. 

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New Brunswick, NJ, United States of America

Richard Lutz