Vive Crop Protection Inc.

Axela Inc.

Axela Biosensors Inc.

Vive Nano, Inc.

Northern Nanotechnologies, Inc.

Richard Loo

Jane B Goh

Cynthia M Goh

Jose Amado Dinglasan

M Cynthia Goh

Emina Veletanlic

Darren J Anderson

Richard McAloney

Richard Mcaloney

Raymond Francis Cracauer

Adam Liederman

Rocky Ganske

Pui Tam

MCynthia Goh

In various aspects provided are methods for producing a nanoparticle within a cross-linked, collapsed polymeric material, said method including (a) providing a polymeric solution comprising a polymeric material; (b) collapsing at least a portion of the polymeric material about one or more precursor moieties; (c) cross-linking the polymeric material; (d) modifying at least a portion of said precursor moieties to form one or more nanoparticles and thereby forming a composite nanoparticle. In various embodiments, a non-confined nanoparticle can be produced by complete pyrolysis of the confined nanoparticle, and a carbon-coated nanoparticle by incomplete pyrolysis of the confined nanoparticle.

Composite nanoparticles, nanoparticles and methods for producing same

A method and apparatus for assay of multiple analytes. The method uses a sensing element comprising a substrate upon which is arranged a multiplicity of recognition elements, such that each element is laid out in a predetermined pattern. Each pattern is unique in that it can give rise to a characteristic diffraction pattern in the assay. The patterns may or may not be interpenetrating on the substrate surface. The method of detecting multiple analytes includes contacting the medium of analytes with the patterned substrate, illuminating the substrate by a light source, and detecting any resultant diffraction image. The pattern of diffraction and the intensity of the diffracted signal provides information about the existence of specific analytes and their quantification.

Method and apparatus for assay for multiple analytes

A composite nanoparticle comprising a nanoparticle confined within a cross-linked collapsed polyelectrolyte polymer wherein the nanoparticle comprises a charged organic ion.

Composite nanoparticles containing organic ions

The present invention relates to a method and apparatus for detecting analytes in a medium, and more particularly the present invention relates to an assay based on light diffraction which appears or changes upon the binding of analytes to their specific receptors laid out in patterns on a substrate, which has high sensitivity due to the appropriate choice of such patterns. The present invention is based on the principle that the pattern of recognition elements, which gives rise to the diffraction of the incident light in a diffraction-based assay, can be chosen in such a way so as to facilitate detection, and to enhance the signal to be detected compared to known gratings such as parallel straight lines. In one aspect the substrate itself has a surface topography designed to enhance the diffraction pattern signals. In another aspect the substrate is a diffractive optic element having the analyte-specific receptors affixed to the optic element. In another aspect the diffractive optic element is used as a master stamp for producing patterns of analyte-specific receptors which give the signal enhancements.

Method and apparatus for assay based on light diffraction

A method for producing a composite nanoparticle, including the steps of: changing the conformation of a dissolved polyelectrolyte polymer from a first extended conformation to a more compact conformation by changing a solution condition so that at least a portion of the polyelectrolyte polymer is associated with a precursor moiety to form a composite precursor moiety with a mean diameter in the range between about 1 nm and about 100 nm; and cross-linking the polyelectrolyte polymer of the composite precursor moiety to form a composite nanoparticle.

Producing composite nanoparticles

A method for producing a composite nanoparticle, including the steps of, collapsing at least a portion of a polyelectrolyte polymer in solution about one or more precursor moieties to form a composite precursor moiety having a mean diameter in the range between about 1 nm and about 100 nm, wherein the polyelectrolyte polymer has an extended conformation in a first solution state and a more compact conformation in a second solution state; and cross-linking the polyelectrolyte polymer of the composite precursor moiety to form a composite nanoparticle wherein the precursory moiety is a charged organic ion.

Producing composite nanoparticles containing organic ions

In various aspects provided are methods for producing a nanoparticle within a cross-linked, collapsed polymeric material. In various embodiments, the methods comprise (a) providing a polymeric solution comprising a polymeric material; (b) collapsing at least a portion of the polymeric material about one or more precursor moieties; (c) cross-linking the polymeric material; (d) modifying at least a portion of said precursor moieties to form one or more nanoparticles and thereby forming a composite nanoparticle.

An apparatus for producing patterns on a surface of a substrate. The apparatus includes a rigid support such as a rigid tubular structure having first and second opposed ends and a fluid flow passageway extending therethrough. A printing stamp is attached at one of the opposed ends of the rigid support. The printing stamp has a flexible diaphragm portion which has an outer surface which is coated with one or more materials in a pre-selected pattern. A pneumatic pressurizing mechanism communicating with an inner surface of the flexible diaphragm portion through the fluid flow passageway is used to bias the flexible diaphragm portion outwardly into intimate and uniform contact with the surface of the substrate for transferring the pre-selected pattern onto the substrate surface. The rigid tubular supports are attached to a robotic positioning mechanism for providing control of positioning of the stamp relative to the substrate surface.

Growing community of inventors

Toronto, Canada

Richard Loo