Smithkline Beecham Corporation

Other

US Government As Represented by the Secretary of the Army

Affinium Pharmaceuticals, Inc.

Richard Lloyd Warren

Christopher Michael Traini

Michael Arthur Lonetto

Sanjoy Biswas

David John Holmes

Leslie Marie Palmer

Magdalena Zalacain

John Edward Hodgson

Michael Terence Black

Min Wang

Deborah Dee Jaworski

Karen Anne Ingraham

Jason Craig Fedon

Richard Oakley Nicholas

James Raymond Brown

Martin M Rosenberg

Alison Francis Chalker

Anna Lisa Kosmatka

Martin Karl Russel Burnham

Judith M Ward

Lisa Kathleen Shilling

David Justin Charles Knowles

Christine Marie Debouck

Jeffrey L Mooney

Raymond Winfield Reichard

Julie M Pratt

Yi Yi Zhong

Chi Young So

Thomas B Mathie

Patrick Vernon Warren

Stephanie Van Horn

Robert King Stodola

Martin Karl Burnham

David Justin Knowles

Martin Karl Russell Burnham

Elizabeth Jane Lawlor

John Peter Throup

Nicola Gail Wallis

Damien McDevitt

Andrew P Fosberry

Alison Frances Chalker

Karen M O'Dwyer

Daniel Robert Sylvester

Martin K R Burnham

Caroline Perry

Elizabeth J Lawlor

Lisa Kathleen Katz

Chi Yong So

Howard Kallender

Stewart Campbell Pearson

Michael N Gwynn

John E Hodgson

Tong Li

Charles H Hoke

Gerhardt G Schurig

Stephen M Boyle

Alexander Philip Bryant

J Robert Putnak

Jennifer E Ray

Chantal Myriam Petit

Annemarie St John

Huo-Shu H Houng

Nammalwar Sriranganathan

Ronald Dean Sholders

Mikeljon Nikolich

David Hoover

Luther E Lindler

Ashok Kumar Srivastava

Lori Romine

Jeff Mooney

Chanal Myriam Petit

Serry Sousa

Ted L Hadfield

John R McOulston

Yi Y Zhong

Michael Terance Black

This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Compounds

The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.

Peptidyl t-RNA hydrolase (PTH)

The invention provides Defl polypeptides and DNA (RNA) encoding Defl polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Defl polypeptides to screen for antibacterial compounds.

Defl

The invention provides Phosphatidylglycerophosphate Synthase polypeptides from (&ldquo;pgsA polypeptides&rdquo;). Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.

Phosphatidylglycerophosphate synthase from Staphylococcus aureus

The invention provides pgsA polypeptides and polynucleotides encoding pgsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.

PgsA

The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.

ribB

Live Brucella vaccines and methods for preparing the live vaccines protective against brucellosis are described. The vaccines are prepared by introducing a deletion in the rfbU gene of a strain of Brucella which results in attenuation of the strain while retaining the desired immunogenicity to initiate a protective immunogenic response. Other strains with varying levels of attenuation are described.

Live vaccine against Brucellosis

The invention provides Def1 polypeptides and DNA (RNA) encoding Def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Def1 polypeptides to screen for antibacterial compounds.

Def1

The invention provides histidine kinase polypeptides and polynucleotides encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.

Histidine kinase

The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.

inFB

The invention provides ysxC polypeptides and polynucleotides encoding ysxC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ysxC polypeptides to screen for antibacterial compounds and for detecting

YsxC from Staphylococcus aureus

The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.

trmD

The invention provides secA2 polypeptides and DNA (RNA) encoding secA2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing secA2 polypeptides to screen for antibacterial compounds.

The invention provides FabG polypeptides and polynucleotides encoding FabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabG polypeptides to screen for antibacterial compounds.

Nucleic acids encoding Streptococcus pneumoniae FabG

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Blue Bell, PA, United States of America

Richard Lloyd Warren