Global Life Sciences Solutions USA LLC

Ge Healthcare Bio-sciences Corp.

General Electric Company

Cytiva Sweden Ab

Richard Lee Damren

Colin R Tuohey

Thomas John Erdenberger

Parrish M Galliher

Jonathan A Kenney

Michael Edward Fisher

Patrick M Guertin

Joseph D Crowell

Klaus Gebauer

Kenneth P Clapp

David Allan Torrey

Ralph Stankowski

Geoffrey L Hodge

Patrik Berndt Akerstrom

Ashraf Said Atalla

Sima Didari

James Pellegrino Alexander

Mats Olsson

Anindya Kanti De

Nagaraj Raghavendra Rao

Nirmal Kumar Thanikachalam

Anindya Sengupta

David Lawrence Brazell

Wei Jin

Roberto Miguel Cabral

Sampath Telikcherla Kandala

John Swibes

Peter A Mitchell

Colin Touhey

Patric Fricking

Patrick Guertin

Parish M Galliher

Ted Deloggio

Jiyoung Lee

Sampath Telikherla Kandala

Peter Mitchell

A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.

Housing for holding a flexible bioprocess bag and method for assembling the bag in the housing

Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.

Continuous recovery harvest bag

The system and method of the invention pertains to an axial flux stator is implemented to replace the drive-end magnets and the drive motor. The axial flux stator comprises a control circuit to control the voltage and current provided to the stator, to measure the torque and speed of rotation, and to measure the magnetic flux and magnetic flux density produced by the axial flux stator and impeller magnets, individually or in combination. The axial flux stator comprises a plurality of current carrying elements to produce magnetic flux in an axial direction and drive the impeller.

Magnetic mixers

A bioprocess mixer (), which comprises: &#x2014;a support vessel () with at least one side wall () and a bottom wall (), where the walls define a support vessel inner volume (), and at least a first () and a second () magnetic impeller drive unit; and &#x2014;a flexible bag () adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (), a bag bottom wall () and a bag top wall () defining a bag inner volume (), and at least a first () and a second () magnetic impeller rotatably attached to a bag wall in the bag inner volume.

Bioprocess mixer

An apparatus for draining a bioreactor vessel includes a tubular body portion having an interior passageway, and at least one aperture in the tubular body portion providing for fluid communication with the interior passageway, the tubular body portion being configured for positioning at a bottom of a vessel, and a suction tube having a first end configured for fluid coupling with the tubular body portion, and a second end configured for fluid coupling with a port in a sidewall of the vessel.

System, method and apparatus for draining a bioreactor vessel

Housing for holding a flexible bioprocess bag

A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.

Probe assembly

The invention discloses a bioreactor apparatus () for cultivation of cells comprising: a) a disposable bioreactor vessel () with one or more walls () defining an inner volume (), at least one port () in a wall, wherein the disposable bioreactor vessel is positioned in a rigid support structure (); and b) a heater (), capable of heating an amount of culture medium to a target temperature in the range of 55-95&#xb0; C., while the amount of culture medium is being confined in or conveyed to the inner volume.

Inactivation of viruses

Disclosed herein is a system and method for condensing moisture in a gas stream entering or leaving a bioreactor, the system comprising: a contact condenser container fluidically coupled to the bioreactor through an exhaust line; a condensate accumulator fluidically coupled to the contact condenser container through at least a first condensate line and a second condensate line; the condensate accumulator further fluidically coupled to the bioreactor through a condensate overflow line; a first condensate control device disposed on the first condensate line and configured to control a flow of condensate leaving the contact condenser container and entering the condensate accumulator; and a second condensate control device disposed on the second condensate line and configured to control a flow of condensate leaving the condensate accumulator to be mixed with the gas stream.

System and method for condensing moisture in a bioreactor gas stream

The aspects of the disclosed embodiments generally relate to an apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments also generally relate to a method of using such apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments generally relate to antifoam systems, methods and apparatus, and more particularly, to an antifoam device operably connected to a single use biobag.

Passive automatic antifoam delivery system for use with single-use bioreactors

Disclosed is a jacketed, tiered baffle, bioreactor tank comprising an outer cylindrical-shaped jacket and a cylindrical tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered baffles configured for routing a heat exchange fluid around the entirety of the outer tank surface, the cylindrical tank disposed axially within the outer cylindrical-shaped jacket. The outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid.

Temperature controlled support surfaces for single use flexible wall systems

Growing community of inventors

Marlborough, MA, United States of America

Richard Lee Damren