Inner Vision Imaging, Inc.

Accuri Cytometers, Inc.

Genomic Solutions Inc.

Richard Lawrence Fisher

Steven Henke

Richard Farkas

Collin Anderson Rich

Nathaniel C Bair

Claus Werner Buchholz

David Carter

George Harold Byrkit

Allison Christyne Bliton

The preferred embodiments of the invention is an optical system for a flow cytometer including a flow channel with an interrogation zone, and an illumination source that impinges the flow channel in the interrogation zone from a particular direction. The optical system preferably includes a lens system and a detection system. The lens system preferably includes multiple lens surfaces arranged around the flow channel and adapted to collect and collimate light from the interrogation zone. The detection system preferably includes multiple detectors adapted to detect light from the lens system. Each detector preferably includes a local filter that independently filters for specific wavelengths. Thus, the user may easily swap the filters in any order to achieve the same detection parameters.

Optical system for a flow cytometer

An endoscope assembly is disclosed having a housing adapted to be manipulated by medical personnel, such as a surgeon. An elongated lens tube has one end secured to the housing while an elongated stage is removably secured to the housing so that the stage encompasses and is coaxial with the tube. The stage together with the lens tube are adapted for insertion into the cavity of a body. A lens assembly provided within the lens tube relays the optical image from the free end of the stage to the housing. A lens assembly within the housing, furthermore, varies the magnification of the image between macroscopic magnification and microscopic magnification in which tissue may be examined on a cellular level. For macroscopic magnification, white light is transmitted through the lens tube as well as reflected back from the target tissue through the lens tube and to the housing. For microscopic examination, laser radiation is utilized in lieu of the white light illumination. A line scanning confocal assembly contained within the housing enables microscopic examination of the target tissue at varying levels into the tissue from the end of the stage.

Endoscope

Endoscope having microscopic and macroscopic magnification

An automated CCD-based imaging system is disclosed which may be used for the automated acquisition, compilation, and analysis of images of fluorescently labeled samples of different types, including fluorescently-labeled gene chip arrays.

Automated, CCD-based DNA micro-array imaging system

An endoscope assembly is disclosed having a housing adapted to be manipulated by medical personnel, such as a surgeon. An elongated lens tube has one end secured to the housing while the free end of the lens tube is adapted for insertion into a cavity of a body. At least one, and preferably several, lens assemblies are longitudinally slidably mounted within the lens tube and movable between longitudinally spaced positions within the lens tube. A drive mechanism is mounted to the housing and mechanically coupled to each lens assembly to move the lens assemblies longitudinally within the lens tube independently of one another. In doing so, the lens assemblies provide varying degrees of magnification between low or macroscopic magnification and microscopic magnification at the free end of the lens tube. A stage is also detachably secured over the lens tube and has a transparent window across its end adjacent the free end of the lens tube. In use, the stage window is positioned against target tissue within a human cavity while the lens assemblies are longitudinally displaced within the lens tube to obtain the desired magnification. Strands extending through and/or connected to the lens groups are used to longitudinally displace the lens groups.

Growing community of inventors

Ann Arbor, MI, United States of America

Richard Lawrence Fisher