William H. Rorer, Inc.

Rorer Pharmaceutical Corporation

Richard L Riley

George H Douglas

William L Studt

John Yelnosky

Chong M Won

George A Condouris

Billy J Chou

This invention relates to a method of lowering blood pressure in humans and mammals using 2,6-disubstituted phenyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, haloacyloxy, or acyloxy group and to novel 2,6-disubstituted phenyl amidinoureas which possess pharmaceutical properties, including blood pressure lowering activity.

Substituted phenyl amidinoureas

A method of inducing blood pressure reduction in humans and mammals by administering 2,6-disubstituted phenyl N-alkyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, acyloxy or halo acyloxy group and a novel class of amidinourea compounds having pharmaceutical uses, including blood pressure lowering activity.

Amidinoureas substituted in both the urea and amidino nitrogen positions

This invention relates to a composition and method of treating congestive heart failure in warm blooded animals, employing substituted phenylamidinourea compounds as the active agents.

Method of treating congestive heart failure

1,4-Disubstituted-1,2-dihydro-1,3,5-triazin-2-ones are used to block conduction of high frequency nerve impulses by selectively acting to substantially completely block high frequency impulses without significantly blocking conduction of a single impulse. The effect is reversible when the drug is withdrawn.

Method for blocking high frequency nerve stimulation

Scours in animals, particularly new-born calves, lambs, piglets and foals are treated with a compound containing an effective amount of an antidiarrheal amidinourea.

Method of treating scours

Multiple daily dosing with amidinoureas of the formula ##STR1## produces a significant and sustained decrease in blood pressure in humans.

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North Wales, PA, United States of America

Richard L Riley