Eastman-kodak Company

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Richard L Detwiler

Ignazio S Ponticello

Richard C Sutton

Merrit Nyles Jacobs

Jon N Eikenberry

Thomas R Kissel

Daniel S Daniel

John W Sutherland

Andrew M Kirsch

Charles H Appell

Brooke P Schlegel

Stephen C Hasselberg

David M Taylor

Daniel A Nealon

James E Love, Jr

John E Hamann

Marsha D Bale Oenick

Robert J Ferris

Improved dry-operative ion-selective electrodes and their use are described. The dry-operative ion-selective electrodes include an internal reference electrode comprising a water-soluble salt dispersed in a polymer binder consisting essentially of a monomer having at least one carboxyl group and a hydrophobic monomer. The polymer provides reduced brittleness, good interlayer adhesion and high salt tolerance.

Polymeric compositions for ion-selective electrodes

A dry multilayer analytical element for assaying transaminases wherein the analytical element comprises:

Dry multilayer analytical elements for assaying transaminases

A multilayer analytical element has been prepared for accurate and rapid colorimetric determination of ethanol in aqueous specimens using alcohol dehydrogenase and an oxidized nicotinamide coenzyme. The element includes at least one reagent layer beneath a porous spreading layer. This reagent layer has a crosslinked polymeric binder prepared, in part, with a polymerizable monomer having a halomethylcarbonyl, haloethylcarbonyl, halomethylsulfonyl or haloethylsulfonyl group. Alcohol dehydrogenase is in a layer of the element for reaction with the analyte.

Multilayer analytical element containing crosslinked binder and method

A multilayer analytical element has been prepared for accurate and rapid colorimetric determination of ethanol in aqueous specimens using alcohol dehydogenase and an oxidized nicotinamide coenzyme. The element includes two reagent layers beneath a porous spreading layer. The element also contains niacinamide in one or more layers to reduce the interference from alcohols other than ethanol.

Multilayer analytical element containing niacinamide and method for the

A multilayer analytical element has been prepared for accurate and rapid colorimetric determination of ethanol in aqueous specimens using alcohol dehydogenase and an oxidized nicotinamide coenzyme. The element includes three reagent layers beneath a porous spreading layer. The middle reagent layer has a crosslinked hydrophilic binder, while the other two reagent layers have uncrosslinked binders. In addition, both uncrosslinked reagent layers include a relatively high amount of a buffer having a primary amine, which buffer maintains the layer pH at from about 8 to about 10. Alcohol dehydrogenase is in the reagent layer next to the porous spreading layer.

Multilayer analytical element containing primary amine buffer and method

An analytical element for quantitatively assaying an analyte by measuring reflection density in the range 320 to 360 nm. The element comprises a reagent layer and a registration layer. One of such layers contains a dye which has a low absorbtivity band from 320 to 360 nm and a high absorbtivity band from 640 to 720 nm.

Analytical elements containing non-reactive blocking dyes

A colorimetric assay for the determination of conjugated, unconjugated or total bilirubin in biological fluids can be carried out with an improved analytical element. This element comprises a support having thereon a substantially gelatin-free mordant layer comprising a positively-charged interactive mordant having at least one binding site for bilirubin, a radiation-blocking layer, and a porous spreading layer. This element does not contain any colorimetric or fluorometric interactive compositions for bilirubin other than the mordant.

Method for the determination of bilirubin and an element useful therein

An overcoat composition for use in ion-selective electrodes comprises: (a) a discontinuous liquid phase comprising an oleophilic solvent dispersed within a continuous phase comprising a hydrophilic binder; (b) a complexing agent useful for extracting oleophilic anions; (c) a buffer which provides a pH in the range of from about 7.5 to about 9.5 under conditions of use; and (d) a nucleating agent. This overcoat composition is particularly useful in ion-selective electrodes for determination of CO.sub.2.

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Webster, NY, United States of America

Richard L Detwiler