Cancer Research Campaign Technology Limited

Richard Knox

Thomas Connors

Roger Sherwood

Michael Jarman

Frank Friedlos

Gillian Anlezark

Anthony Mauger

Roger Melton

Caroline Joy Springer

A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R.sup.1 NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.2 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.

Bacterial nitroreductase for the reduction of CB1954 and analogues

Bacterial nitroreductase gene-prodrug system

A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R--NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.1 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.

Bacterial nitroreductase for the reduction of CB 1954 and analogues

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Sutton, United Kingdom

Richard Knox