New York University

Research Foundation for Mental Hygiene, Inc.

Richard Kascsak

Thomas M Wisniewski

William Ted Brown

Daryl Spinner

Giuseppe LaFauci

Henrieta Scholtzova

The present invention is directed to a method of preventing or reducing amyloid deposition in a subject. This method involves selecting a subject with amyloid deposits and stimulating the innate immune system of the selected subject under conditions effective to reduce the amyloid deposits. Also disclosed is a method of preventing or treating cerebral amyloidosis and Alzheimer's Disease in a subject by administering to the selected subject an agent that stimulates the innate immune system. In addition, a composition useful for the stimulation of the innate immune system of a subject exhibiting symptoms associated with amyloid deposition is disclosed.

Preventing and treating amyloid-beta deposition by stimulation of innate immunity

A system and method for the detection and quantification of fragile X mental retardation protein (FMRP) in human tissue and blood samples. The system includes several high avidity monoclonal antibodies that may be provided on Xmap microspheres to capture FMRP from a tissue or blood specimen. The resulting complex is reacted with a polyclonal anti-FMRP rabbit antibody and then mixed with an anti-rabbit IgG antibody conjugated to phycoerythrin. Fluorescence emitted from the resulting complex is a function of the amount of FMRP present in the specimen.

System and method for quantifying fragile X mental retardiation 1 protein in tissue and blood samples

System and method for quantifying fragile X mental retardation 1 protein in tissue and blood samples

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Morganville, NJ, United States of America

Richard Kascsak