Merck + Co., Inc.

Richard K Jansson

Gerald F Bills

James E Curotto

Deborah L Zink

Jerrold M Liesch

Richard L Monaghan

Robert E Schwartz

Fernando Pelaez

Robert A Giacobbe

Dennis M Schmatz

Anne W Dombrowski

John R Thompson

Suzanne M Mandala

Guy H Harris

Francisca Vicente

Sandra A Morris

Angela Basilio

Wendy S Horn

Sarah J Dreikorn

Rosalind G Jenkins

Mark Rattray

Joan A Lasota

Teresa Diez

Disclosed is a method for controlling phytopathogenic fungi using pure strains of ATCC 74386 and fungus ATCC 74387. Further, methods of producing a sordarin compound are disclosed. The method includes cultivating each strain separately in a nutrient medium containing assimilable sources of carbon and nitrogen and recovering the compound. A sordarin compound of formula I is also disclosed. Also an antifungal composition containing a sordarin compound is also disclosed.

Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control

There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.

Antifungal agents

A compound having the formula ##STR1## which is useful as an antifungal agent and for the treatment and control of several agricultural phytopathogens, including Phytophthora infestans, is disclosed.

Antifungal agent

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Doylestown, PA, United States of America

Richard K Jansson