Other

University of Toledo

Mcgill University

American Diagnostica, Inc.

Richard K Hart

Jerzy Jankun

Shafaat A Rabbani

Joseph R Polizzi

The present invention relates to the use of molecules capable of specifically binding a urokinase plasminogen activator receptor (uPAR) as diagnostic reagents for the detection of metastases in vivo. Such metastases can include, but are not limited to, micrometastases.

Urokinase plasminogen activator receptor as a target for diagnosis of

A method of delivering a medicament to the surface of a cancer cell and transferring the medicament into the cancer cell using an activated plasminogen activator material such as a plasminogen activator inhibitor type-1 or type-2 (PAI-1, PAI-2). The medicament is coupled to PAI-1 or PAI-2 to form a reaction product that is coupled with the urokinase plasminogen activator (uPA) that is bound to the cell surface by the uPA receptor (uPAR). The medicament is coupled to PAI-1 or PAI-2 (for example, using a preserving agent such as saporin) in such a way that the medicament does not interfere with active sites responsible for binding to uPA or LRP proteins responsible for the internalization of the plasminogen activator material/conjugated medicament. The conjugated medicament prevents the conversion of the plasminogen activator inhibitor material into its latent inactive form. The resulting complex is internalized into the cancer cell to deliver the medicament within the cell.

Method of delivery of a medicament to a cancer cell using a pathway of

A clip apparatus for releasably securing a fender flare onto a vehicle fender. The apparatus utilizes a bolt which is tightened so as to engage the flare and the fender and rigidly retain the flare on the fender.

Fender flare clip apparatus

A quickly removable curtain assembly for covering the inside of a vehicle windshield. The curtain assembly includes an opaque cloth panel for covering the windshield and front side windows of a vehicle such as a recreation vehicle or van.

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Cerritos, CA, United States of America

Richard K Hart