Teva Animal Health, Inc.

Ortho Pharmaceutical Corporation

Richard K Farng

Steven Mrha

James A Mezick

Shirley M Ng

Ba Cuong Tu

Gerard J Gendimenico

Chung-Tsin Chiu

Kenneth W Kwochka

Stanley B Wrobel, Jr

The invention provides novel compositions of water-insoluble corticosteroid drug in combination with antimicrobial agents and very low concentrations of polymers and surfactants for topical, otic and ophthalmic treatment. The invention provides stable aqueous suspension where the ingredients remain in such a state so as to allow for immediate re-suspension, when desired, even after extended periods of settling. The invention provides also a method for treating inflammation with low systemic absorption and side-effects of the corticosteroid.

Corticosteroid having low systemic absorption

Novel wash and carrier solutions ideally suited for topical administration (e.g., as wash solutions and as carrier solutions). The solutions described herein are non-toxic, non-irritating, isotonic, possess non-specific broad-spectrum antimicrobial properties, and have an alkaline pH. Also disclosed are sterile preparations of the solutions and methods of using the same.

Antimicrobial wash and carrier solutions and uses thereof

Antimicrobial wash and carrier solutions, and uses thereof

This invention relates to aqueous gel retinoid compositions and their methods of use. More specifically, the aqueous gel retinoid compositions of the invention utilize micronized particles of retinoids, particularly tretinoin, to provide an aqueous gel for topical application of such retinoids to the skin which minimizes skin irritation while retaining drug efficacy.

Aqueous gel retinoid dosage form

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East Brunswick, NJ, United States of America

Richard K Farng