Evofem Biosciences, Inc.

Richard John Holl

Gregory Kaufman

James Garegnani

David Palling

Carol J Braun

Kurt Nielsen

Helen S Pentikis

Method of treating or preventing trichomoniasis orinfection in a subject in need thereof, the method involving administering to the subject a therapeutically effective amount of secnidazole or a pharmaceutically acceptable salt in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules. The subject can also have bacterial vaginosis, is HIV-positive, and/or is suffering with metronidazole-resistant trichomoniasis and/or tinidazole-resistant trichomoniasis. The subject can also be a sexual partner of a person with trichomoniasis. The microgranule formulation can also be administered with paromomycin, tinidazole, metronidazole, boric acid or a combination thereof. Pharmaceutical compositions and uses for treating or preventing trichomoniasis orinfection in a subject in need thereof are also contemplated herein.

Method and pharmaceutical composition for treating or preventing trichomoniasis and uses thereof

The present invention is related to deuterated secnidazole, a prodrug thereof, a hydrate thereof, a solvate thereof, a polymorph thereof, or a pharmaceutically acceptable salt thereof and its use for the treatment of bacterial vaginosis or trichomoniasis in a subject in need thereof. The present invention is also related to pharmaceutical compositions and methods and uses of treating bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, or a combination thereof.

Deuterated secnidazole for use in the treatment of bacterial vaginosis and methods and uses thereof

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Somerset, NJ, United States of America

Richard John Holl