University of South Florida

Richard Jason Connolly

Mark Jeffrey Jaroszeski

Andrew M Hoff

Richard A Gilbert

Jose I Rey

Timothy Fawcett

Gabriel A Lopez-Diaz

Reginald Morley Atkins

Douglas Walter Brown

John Anthony Llewellyn

The present invention provides a system and method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.

Method for electroporation controlled by electrical impedence measurements

The present invention provides a system and a method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. A result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize an electrical treatment for a particular target cell or cellular tissue.

System and method for electroporation controlled by electrical impedance measurements

In one embodiment, controlling the spatial distribution of an electromagnetic field in a system involves determining an inflection frequency for energy applied to the system below which a first spatial distribution results and above which a second spatial distribution results, selecting an excitation frequency to be used to generate an electromagnetic field to be applied to the system based upon the determined inflection frequency, and applying an electromagnetic field generated using the selected excitation frequency.

Systems and methods for controlling the spatial distribution of an electromagnetic field

Cell or tissue permeability to electrical signals can be used to determine the depth of anesthesia of a patient. A method and device is presented to measure, record and control the effects of anesthesia or analgesics on humans and/or animals. Based on impedance values of tissues measured at single, multiple, or a domain of frequencies, the system detects tissue permeability alterations as determined by electromagnetic, impedance, and/or dielectric spectroscopy. The system measures the permeability of tissues to electrical signals and correlates these values to the depth of anesthesia or sedation level of a certain tissue or individual. This method and device can be used to measure the effects of anesthesia or analgesic for either local or systemic administration.

Method and device for anesthesiology measurement and control

A method for facilitating a delivery of a molecule into an interior space of a cell includes the steps of introducing a molecule into a biological structure comprising a cell and applying a substantially continuous low-level electric field, in the form of non-thermal plasma (ionized gas) generated by a direct current voltage applied to an electrode, to the molecule and biological structure. The field is applied for a duration sufficient to effect a change in porosity the cell of the biological structure sufficient to facilitate an entry of a desired molecule into an interior thereof.

Method to facilitate directed delivery and electroporation using a charged stream

A device and method to cause hair loss or prevent or inhibit hair growth. The invention uses plasma (ionized gas) that is generated by flowing gas in close proximity to an electrode that has a high potential applied to it. The result is a stream of charged gas particles that are directed to the skin that contains hair. The flowing stream of gas is held above the surface of the skin. Additionally, a grounded conductive material is affixed to the skin to dissipate any charge buildup on the skin and focus the plasma.

Growing community of inventors

Riverview, FL, United States of America

Richard Jason Connolly