The Uab Research Foundation (the University of Alabama at Birmingham)

Arch Development Corporation

The University of Chicago

Richard J Whitley

Bernard Roizman

Ralph R Weichselbaum

George Yancey Gillespie

James MacDowell Markert

Jacqueline Nuss Parker

Jacqueline Ness Parker

Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.

Treatment of tumors with genetically engineered herpes virus

An anti-cancer pharmaceutical composition includes a herpes simplex virus (HSV) vector into which a nucleic acid sequence encoding for an anti-cancer agent selected from interleukin-12, GM-CSF, and CD has been inserted. A method of treatment of a patient suffering from cancer includes administering to the patient the anti-tumor pharmaceutical composition including a HSV vector having a nucleic acid sequence encoding for an anti-cancer agent selected from interleukin-12, GM-CSF, and CD inserted therein.

Herpes simplex virus expressing foreign genes and method for treating cancers therewith

Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

Recombinant herpes simplex virus useful for treating neoplastic disease

An anti-cancer pharmaceutical composition includes a herpes simplex virus (HSV) vector into which a nucleic acid sequence encoding an anti-cancer agent selected from interleukin-12, GM-CSF, and CD has been inserted. A method of treatment of a patient suffering from cancer includes administering to the patient the anti-tumor pharmaceutical composition including an HSV vector having a nucleic acid sequence encoding an anti-cancer agent selected from interleukin-12, GM-CSF, and CD inserted therein.

Growing community of inventors

Birmingham, AL, United States of America

Richard J Whitley