Other

University of California

Richard J Reimer

Robert H Edwards

Erik Jorgensen

Elizabeth E Bellocchio

Steven L McIntire

Robert T Fremeau, Jr

Kim Schuske

This invention pertains to the identification of a novel class of glutamate transporters. In particular, this invention pertains to the discovery that proteins originally considered to perform an entirely different function (BNPI, DNPI, etc.), in fact, transport glutamate into synaptic vesicles. Designated VGLUT glutamate transporters, the transporters provide good targets with which to screen for modulators of glutamate uptake into synaptic vesicles.

Glutamate transporters

Disclosed are invertebrate and vertebrate synaptic vesicle amino acid transporter compositions which define a novel family of transporter proteins, recombinant vectors and cells comprising nucleic acid sequences encoding vertebrate synaptic vesicle amino acid transporter proteins and antibodies directed against such proteins. Also disclosed are methods for utilizing such compositions in screening assays and treatment regimens.

Vesicular amino acid transporter composition and method

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San Francisco, CA, United States of America

Richard J Reimer