Eastman-kodak Company

Other

Mednovus, Inc.

Virtual-eye.com

Quantum Magnetics, Inc.

Eastman Technology, Inc.

Orincon Corp.

Sonique Surgical Systems, Inc.

Richard J McClure

R Kemp Massengill

Frederick J Jeffers

Sankaran Kumar

Peter Victor Czipott

Dariusz Wroblewski

Stephen Wolff

Lowell J Burnett

James U Lemke

Jay W Pettegrew

William Frank Avrin

Kanagasabai Panchalingam

Johannes Braeuning

William W French

Chao S Chi

Billy W Day

Tulio T Parisi

John Moses Osepchuk

Frederick John Jeffers

Stefan Schueller

Kenneth J Nesslage

Esther S Massengill

William J Avrin

Compounds, compositions and methods for the detection and diagnosis of Parkinson's disease. Derivative lycerophosphocholine (GPC) compounds are used as a detection and diagnostic aid to measure progression of Parkinson's disease by detecting GPC binding to &#x3b1;-synuclein. Derivative CPG compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging (MRI) and/or positron emission tomography (PET) applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the detection, diagnosis and assessment of the progression of Parkinson's disease may be achieved.

Compounds, compositions and methods for medical imaging of Parkinson's disease

A method to screen individuals specifically for paramagnetic or ferromagnetic objects they may be carrying or wearing, before they enter the high-field region of an MRI suite. The device used comprises either a screening portal or a compact, hand-held magnetic gradiometer and its electronics. The method places all of the sensor arrays in close proximity to all parts of a subject's body, for screening purposes.

Method for excluding magnetic objects from magnetic resonance imaging facility

Compounds, compositions and methods for the diagnosis of Alzheimer's disease. Synthesized Glycerophosphocholine (GPC) may be used as a diagnostic aid to measure progression of Alzheimer's disease. GPC is a membrane phospholipid metabolite that is capable of binding specifically to the &#x3b2;-turn of beta amyloid (A&#x3b2;) peptide. Compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging and/or positron emission tomography applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the diagnosis and assessment of the progression of Alzheimer's disease may be achieved.

Compounds, compositions and methods for medical imaging of neuropsychiatric disorders

Carnitines are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to produce longer chain fatty acid esters of carnitines such as polyunsaturated fatty acid esters including eicosapentaenoyl-L-carnitine and/or docosahexaenyl-L-carnitine in germinating plant seeds. The resulting products from the plant seeds are used as a natural nutritional source of powerful human antioxidants.

Compounds, compositions and methods for producing antioxidants from carnitine

A method and apparatus to screen individuals specifically for paramagnetic or ferromagnetic objects they may be carrying or wearing, before they enter the high-field region of an MRI suite. The device comprises either a screening portal or a compact, hand-held magnetic gradiometer and its electronics. The device places all of the sensor arrays in close proximity to all parts of a subject's body, for screening purposes.

Magnetic resonance imaging screening method and apparatus

A ferromagnetic detection pillar having one or more applied magnetic field sources and one or more magnetic field sensors, with the magnets and sensors arranged and adapted to detect a ferromagnetic threat object on one side of the pillar. A detection device, such as a motion detector or infrared detector, is also provided, to detect the presence of an object on a selected side of the pillar. A single free-standing pillar can be used, or two or more free-standing pillars can be arranged to constitute a variable aperture detection portal. Single sensors or multiple-sensor configurations can be used.

Ferromagnetic detection pillar

A method and an apparatus are disclosed, to screen patients or other areas for ferromagnetic objects, particularly for use intra-operatively in an operating room. The device comprises at least one magnetic field source, at least one magnetic gradiometer, and the associated electronics. The field source and the gradiometer are supported by an arm structure which can be manipulated to position the field source and the gradiometer at one or more positions near areas of interest, such as areas on a patient or other subject, and to orient the field source and the gradiometer so that the axis of the magnetic field is arranged along three different non-parallel, non-coplanar, axes to ensure detection of any ferromagnetic object regardless of its shape and orientation. The device can be manipulated to place the sensor arrays in close proximity to selected parts of a subject's body, for screening purposes. Two field sources and two gradiometers can be provided, for positioning on two sides of a portion of the subject's body, such as the head.

Screening method and apparatus

A method and apparatus to screen individuals specifically for paramagnetic or ferromagnetic objects they may be carrying or wearing, before they enter a controlled area. The device comprises a screening portal, including multiple sensor arrays and associated electronics. The device places the sensor arrays in close proximity to a subject's body, including the head and feet if desired, for screening purposes. The portal can have multiple excitation sources oriented to generate a multi-axis excitation field, and multi-axis sensors. The portal can also have an interlock with the door of the controlled area.

A method and apparatus to screen individuals specifically for paramagnetic or ferromagnetic objects they may be carrying or wearing, before they enter a security area. The device comprises either a screening portal or a compact, hand-held magnetic gradiometer and its electronics. The device places all of the sensor arrays in close proximity to all parts of a subject's body, for screening purposes.

Security screening method and apparatus

Methods and apparatus for minimizing the effects of temperature drift in a magnetic susceptibility measurement instrument, such as an instrument used in pre-MRI screening for the presence of ferromagnetic foreign bodies. The magnetic field source and magnetic sensors can be combined into a single, rigid unit. The stability and sensitivity required in high quality magnetic susceptibility measurements can be achieved through symmetrical design of the source-sensor unit, minimization of thermal stresses, minimization of temperature variations, use of materials with low thermal expansion coefficients, or through appropriate combinations thereof. Use of patient eye movement where an eye is being screened, use of a water bag between the patient and the instrument, or use of telemedicine to facilitate performance of the necessary computations can also be incorporated.

Susceptometers for foreign body detection

A system for testing and quantifying visual field and other visual function information in a head-mounted virtual reality environment, utilizing a directed image formation device for scanning of a flickering image for display to the test subject. A method and an apparatus are also provided for utilizing a central neural network and a central data bank to perform automatic interpretation of the visual function test parameters obtained in a plurality of visual field testing systems, for a plurality of patients, with control and response signals being transmitted via the Internet. The data produced by the testing systems are automatically analyzed and compared with patterns on which the neural network was previously trained, and clinical diagnoses for pathological conditions are thereby suggested to the respective clinician for each patient.

Flicker and frequency doubling in virtual reality

A sea rescue signaling system including a personal flotation device equipped with a GPS receiver, a satellite radio-telephone, a hydrostatic pressure detector, and a controller. When the pressure detector senses a minimum specified submersion of the device for a minimum specified duration, the controller energizes the GPS and the radio-telephone, then dials a rescue service and transmits a distress signal and position data.

Automated fail-safe sea rescue flotation system

A system for testing and quantifying visual field and other visual function information in a head-mounted virtual reality environment, utilizing a directed image formation device for scanning of an image onto the retina of the test subject. A method and an apparatus are also provided for utilizing a central neural network and a central data bank to perform automatic interpretation of the visual function test parameters obtained in a plurality of visual field testing systems, for a plurality of patients, with control and response signals being transmitted via the Internet. The data produced by the testing systems are automatically analyzed and compared with patterns on which the neural network was previously trained, and clinical diagnoses for pathological conditions are thereby suggested to the respective clinician for each patient.

Visual function testing with virtual retinal display

A method and apparatus for testing the visual field of a patient, with a head mounted display, which displays a central fixation icon and a variable peripheral stimulus icon, and which senses the responses of the patient by tracking the gaze of the patient, as the gaze shifts between the central fixation icon and the peripheral stimulus icon.

Kinetic visual field apparatus and method

A system and method for automatically interpreting the results of visual field tests with a computer programmed to perform a continuously updated protocol derived from the interpretation of numerous visual field tests by experts in interpretation of visual field test results.

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San Diego, CA, United States of America

Richard J McClure