Lantheus Medical Imaging, Inc.

Collagen Medical, LLC

Oasis Pharmaceuticals, LLC

Anchor Therapeutics, Inc.

Acer Therapeutics Inc.

Richard J Looby

Edward H Cheesman

Richard R Cesati

David S Casebier

Thomas David Harris

Simon P Robinson

Padmaja Yalamanchili

Peter Caravan

Aaron Sato

Heike S Radeke

Vincent Jacques

Ajay Purohit

Andrew Kolodziej

Stephane A Dumas

Zhaoda Zhang

Aida Abujoub

Steffi K Koerner

Wei-Chuan Sun

Pedro Benites

Biplab Kumar Das

David R Buckler

Thomas J McMurry

Joel Lazewatsky

L Veronica Lee

Boris Tchernychev

Provided herein are peptides comprising a mutated fragment of a wild-type protease-activated receptor-2 (PAR2). The peptides comprising a hydrophobic moiety can penetrate the cell membrane and act as an antagonist of PAR2. Also provided herein are compositions and cells comprising the peptides and methods of using the peptides.

Protease-activated receptor-2 modulators

Compounds and methods for imaging and/or assessing collagen are described. The compounds can include collagen binding peptides.

Collagen imaging compositions

The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

N-alkoxyamide conjugates as imaging agents

The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched inF. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

Compositions, methods, and systems for the synthesis and use of imaging agents

Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.

Methods for collagen imaging

The invention relates generally to compounds which are allosteric modulators {e.g., positive and negative allosteric modulators, and allosteric agonists) of the G protein coupled receptor for stromal derived factor 1 (SDF-I), also known as the CXCR4 receptor. The CXCR4 receptor compounds are derived from the intracellular loops and domains of the CXCR4 receptor. The invention also relates to the use of these CXCR4 receptor compounds and pharmaceutical compositions comprising the CXCR4 receptor compounds in the treatment of diseases and conditions associated with CXCR4 modulation such as bone marrow transplantation, chemosensitization, cancer, metastatic disease (e.g., cancer), auto-immune disease (e.g., rheumatoid arthritis), fibrosis disease (e.g., pulmonary), AIDS infection, cardiovascular disease, uveitis, inflammatory diseases, celiac disease HIV infection and stem cell-based regenerative medicine.

CXCR4 receptor compounds

Methods of collagen imaging

Growing community of inventors

Reading, MA, United States of America

Richard J Looby