Salutar, Inc.

Nycomed Salutar, Inc.

Richard J Himmelsbach

Scott M Rocklage

Alan D Watson

William C Dow

David B Love

Jo Klaveness

Per Strande

Harald Dugstad

Pangl Rongved

Hydrazide derivatives of polyamides and their medical use as chelating

Linear oligomer polychelant compounds and chelates formed therewith have alternating chelant and linker moieties bound together by amide or ester moieties. The compounds have between 3 and 100 chelant moieties, at least one of which complexes a paramagnetic metal ion. The polychelants and especially their paramagnetic metal polychelates are particularly suitable for diagnostic imaging.

Linear oligomeric polychelant compounds

There are disclosed polychelant compounds, that is multi-site metal chelating agents, and chelates formed therewith. The polychelants and especially their paramagnetic metal, heavy metal or radioactive metal polychelates are particularly suitable for use in diagnostic imaging, heavy metal detoxification or radiotherapy. The polychelants have a linear or branched oligomeric structure comprising alternating chelant and linker moieties bound together by amide or ester moieties the carbonyl groups whereof being adjacent the chelant moieties, each polychelant comprising at least two said chelant moieties capable of complexing a metal ion.

Polychelant compounds

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Pleasanton, CA, United States of America

Richard J Himmelsbach