Merck + Co., Inc.

American Cyanamid Company

Richard J Demchak

Richard John Varsolona

Raymond Cvetovich

James A McCauley

David Lasilla Whitehead

Vito Corso, Jr

The most thermodynamically stable crystalline form of the benzoic acid salt of 4&Prime;-deoxy-4&Prime;-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.

Thermodynamically stable crystal form of 4&Prime;-deoxy-4&Prime;-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation

Their is disclosed a novel solvent-depletion process for making an avermectin/zein composition and the composition itself, which has excellent photostability and unexpected bioavailability to foliar-feeding insects. The process consists of depleting a dilute acidic, basic or alcoholic solvent from an emulsified solution of avermectin, zein, and dilute solvent.

Process for making avermectin/zein compositions

The invention relates in general to aqueous, thermally revisible gels containing d1- or 1-6-phenyl-2,3,5,6-tetrahydro (-) imidazo[2,1-b]thiazole, acylamino derivatives thereof and pharmaceutically acceptable salts thereof, characterized by sub-zero gelation temperatures, storage stability and satisfactory anthelmintic activity. The invention relates in particular to gels containing levamisole, tetramisole, butamisole or benzamisole. The invention further relates to methods of use of the gels for the control of helminths infecting homothermic farm and companion animals.

Anthelmintic levamisole and tetramisole gel compositions

Novel composition comprising in combination a 1,2-dialkyl-3,5-diphenylpyrazolium salt and an acetylenic glycol safener, and a method of utilizing said composition for the selective postemergence control of wild oats in spring wheat, whereby the said safener minimizes the phytotoxic damage frequently caused by said 1,2-dialkyl-3,5-diphenylpyrazolium salt.

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Langhorne, PA, United States of America

Richard J Demchak