Genmab A+s

Biontech Se

Richard Hibbert

Janine Schuurman

Aran Frank Labrijn

Ugur Sahin

Alexander Muik

Esther Cornelia Wilhelmina Breij

Lars Guelen

Bart-Jan De Kreuk

Sina Fellermeier-kopf

Paul Parren

Arnout F Gerritsen

Rob N De Jong

Friederike Gieseke

Joost J Neijssen

David P E Satijn

Patricia Garrido Castro

Jordan Blum

Andreea Ioan

Kristina Nürmberger

Karsten Beckmann

Claudia Paulmann

Ivan Kuzmanov

The present invention provides a binding agent that binds to EpCAM and to CD137 which is useful to treat or prevent a tumor or cancer, or to prevent progression of a tumor or cancer.

Binding agents binding to EpCAM and CD137

The present invention relates to a method for controlling the composition of a mixture of two or more different antibodies, such as tow or more different monoclonal antibodies, using chromatography. The mixture is for use as a drug product and the method includes a controlled downstream process for the production of a predetermined ratio of the two or more different antibodies.

Method for producing a controlled mixture of two or more different antibodies

The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.

Monoclonal antibodies directed against programmed death-1 protein and their use in medicine

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Utrecht, Netherlands

Richard Hibbert