Actinium Pharmaceuticals, Limited

Isotopen Technologien Munchen Ag

Actinium Pharmaceueuticals, Inc.

Richard Henkelmann

Michael Schilp

Tuomo Nikula

Josue Manuel Moreno Bermudez

Eva Kabai

Andreas Turler

Ernst Huenges

Andreas Tuerler

Ernst Hueenges

Mark Harfensteller

Oliver Buck

Andreas Türler

Raffaella Perego

Ernst Hüenges

Mauritius W Geerlings

The present invention describes a method for purification ofAc from irradiatedRa-targets provided on a support comprising a leaching treatment of theRa-targets for leaching essentially for the entirety ofAc andRa with nitric or hydrochloric acid, followed by a first extraction chromatography for separatingAc fromRa and other Ra-isotops and a second extraction chromotography for separatingAc fromPo andPb. The finally purifiedAc can be used to prepare compositions useful for pharmaceutical purposes.

Method for purification of 225AC from irradiated 226RA-targets

The present invention describes a method for purification ofAc from irradiatedRa-targets provided on a support, comprising a leaching treatment of theRa-targets for leaching essentially the entirety ofAc andRa with nitric or hydrochloric acid, followed by a first extraction chromatography for separatingAc fromRa and other Ra-isotops and a second extraction chromatography for separatingAc fromPo andPb. The finally purifiedAc can be used to prepare compositions useful for pharmaceutical purposes.

The invention is directed to a method for the purification of Radium, in particularRa, for target preparation for an essentially pureAc production from available radioactive sources, using an extraction chromatography in order to separate chemically similar elements such as Ba, Sr, and Pb from the desired Ra; wherein said extraction chromatography has an extractant system on the basis of a crown ether. The invention is related to a method for recycling ofRa, for target preparation forAc production from radium sources irradiated with accelerated protons (p,2n), after separation of the producedAc. In this method a combination of the above extraction chromatography and a cation exchange chromatography is used. The obtainedRa is essentially free of the following chemical contaminants consisting of Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Na, Ni, Pb, Sr, V, Zn, and Ba.

Method for the purification of radium from different sources

The present application is directed to a method for the purification of Radium, in particularRa, for target preparation for an essentially pureAc production from available radioactive sources, using an extraction chromatography in order to separate chemically similar elements such as Ba, Sr, and Pb from the desired Ra; wherein said extraction chromatography has an extractant system on the basis of a crown ether. The invention is further related to a method for recycling ofRa, for target preparation forAc production from radium sources irradiated with accelerated protons (p,2n), after separation of the producedAC. In this method a combination of the above extraction chromatography and a cation exchange chromatography is used. The obtainedRa is essentially free of the following chemical contaminants consisting of Ag, Al, As, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Na, Ni, Pb, Sr, V, Zn, and Ba.

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Freising, Germany

Richard Henkelmann