Novartis Ag

Richard Heng

Paul William Manley

Guido Bold

Bernhard Wietfeld

Jeanette Marjorie Wood

Janet Dawson King

Anna Vulpetti

Oliver Simic

Achim Schlapbach

Robert Alexander Pulz

Carsten Spanka

David Carcache

Guido Koch

J&ouml;rg Frei

Birgit Bollbuck

Jorg Eder

Danilo Guerini

Rudolf Waelchli

Laszio Revesz

Joerg Frei

Jörg Frei

Elizabeth Kate Hoegenauer

Florian Gruber

Martin Gunzenhauser

Francesca Perruccio

The present disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein Rthrough Rare as defined herein, and methods of making and using the same.

Compounds and compositions for treating conditions associated with cGAS

The present invention describes new pyrrolo pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel pyrrolo pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.

Pyrrolo pyrimidine derivatives

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases. 

1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives

The invention relates to the treatment of leukemias with an inhibitor of the activity of VEGF receptor tyrosine kinase of the formula I, 

Phthalazine derivatives for treating inflammatory diseases

The invention relates to the treatment of an inflammatory disease, especially an inflammatory rheumatoid or rheumatic disease, and/or pain with an inhibitor of the activity of VEGF receptor tyrosine kinase of the formula I,

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Hegenheim, France

Richard Heng