Fisons Ltd.

Richard Hazard

Roger C Brown

John King

John Mann

Hugh Cairns

Thomas B Lee

John Townend

There is described the compound of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. Processes for making the compound and pharmaceutical, e.g. anti-asthmatic, compositions containing it are also described.

5-(2-Hydroxypropoxy)-8-propyl-4H-1-benzopyran-4-one-2-carboxylic acid

There are described compounds of formula I, ##STR1## in which R.sub.3 represents hydrogen, or alkyl C 1 to 6,

Tricyclic mono-chromone-2-carboxylic acids

There are described compounds of formula I, ##STR1## in which R.sub.3 represents hydrogen, or alkyl C 1 to 6, R.sub.5 represents hydrogen, hydroxy, alkoxy C 1 to 6, alkanoyloxy C 2 to 6, alkenyloxy C 2 to 6, nitro, -NR.sub.1 R.sub.2, halogen, alkyl C 1 to 6, hydroxy-alkyl C 1 to 6, or hydroxy-alkoxy C 1 to 6,

There is provided a process for the preparation of coumarin derivatives of the formula: ##STR1## (wherein R represents substituted or unsubstituted alkyl, aryl or aralkyl, R.sup.1 represents alkanoyl, and the hydroxy and R.sup.1 substituents are ortho to one another) in which a hydroxy-substituted coumarin of the formula: ##STR2## is acylated in the presence of a Friedel-Crafts catalyst. The compounds of formula I are intermediates in the preparation of certain pharmaceutically-active chromones.

Process

Pharmaceutical compounds of formula I, ##SPC1## in which

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Richard Hazard