Novartis Ag

Cornell University

Elanco Tiergesundheit Ag

Novartis Tiergesundheit Ag

Richard Harland

Trent Harbison

Manuel Campos

Dan Keil

Todd Johnson

Thomas Plocher

Nikolaus Osterrieder

Gopinath Raju Seetharaman

Lee David Albee, Ii

Mayur Navnitbhai Patel

Benedikt B Kaufer

Lee David Albee

Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactiveproteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated withinfection.

Cross-reactive determinants and methods for their identification

The disclosure relates generally to the treatment or prevention of disease in cattle. More particularly, the invention is directed to the production and use of modified bovine herpesvirus 1 (BHV-1) and their use in compositions and vaccines that protect cattle from BHV-1 infection while not suppressing the immunological response in the host. In one example, the invention is directed to the use of modified BHV-1, administered with additional immunogens, either through co-administration and/or through administration in combination vaccines, and the use of these vaccines for the protection of cattle from disease. In one example, use of the modified BHV-1 in the administered compositions facilitates an immune response to or against the additional immunogens.

Bovine herpes virus-1 compositions, vaccines and methods

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Mississauga, Canada

Richard Harland