Ceres, Inc.

Richard Hamilton

Roger I Pennell

Delin Liang

Michael F Portereiko

Described are methods and materials for the genetic modification of plants by specific gene targeting and precise editing of nucleic acid sequences in a plant. The methods and materials provided herein enable one to edit the plant genome by design to control the expression of endogenous genes and/or control the transmission and expression of transgenic traits. Provided are also methods of producing plants having a desirable agronomic trait by crossing a transgenic plant expressing a gRNA with a plant expressing a Cas enzyme, and selecting a progeny plant having the desirable agronomic trait or a seed thereof.

Methods for genetic modification of plants

High throughput methods are described for identifying combinations of mutations that can be used to improve a phenotypic feature in an organism. Large populations of organisms (e.g., plants) containing different combinations of mutations can be assessed using the methods.

Methods and materials for high throughput testing of mutagenized allele combinations

High throughput methods are described for identifying combinations of transgenes that can be used to improve a phenotypic feature in an organism. Large populations of organisms (e.g., plants) containing different combinations of transgenes as well as different promoter-coding sequence combinations can be assessed using the methods.

Growing community of inventors

Thousand Oaks, CA, United States of America

Richard Hamilton