Repligen Corporation

International Technidyne Corporation

Richard Hall

Peter Halatin

Yusheng Zhang

Matthew Muller

Robert S Lorincz

A system may include a light source, to generate a probe signal, comprising incident radiation; an optical probe, to direct the incident radiation through a fluid sample; a motor, to move the optical probe along a probe axis, to change a path length of the incident radiation through the fluid sample; and a detector, to receive the incident radiation as attenuated radiation after passing through the fluid sample. The system may include a control system, arranged to: initiate an absorbance measurement by directing movement of the optical probe along the probe axis; direct the light source to emit the incident radiation; and automatically adjust at least one measurement parameter of a set of measurement parameters for the sample measurement, based upon a slope parameter m, wherein m is derived from a rate of change in an intensity of the attenuated radiation with a change in the path length.

Variable path length absorption spectrometer having automated continuous slope measurement

A method includes determining whether a variation in probe radiation intensity meets a stability criterion; directing the probe radiation through a probe, when the probe is disposed at a first position, defining a first path length Lof the probe radiation through the fluid sample; measuring a transmitted intensity Iof the probe radiation after passing through the fluid sample when the probe is disposed at the first position; directing the probe radiation through the probe when the probe is disposed at a second position, defining a second path length Lof the probe radiation through the fluid sample; measuring a transmitted intensity Iof the probe radiation after passing through the fluid sample when the probe is disposed at the second position; and determining a concentration C of a material in the fluid sample based upon L, I, L, and I, when the stability criterion is met.

No-ref-signal slope spectroscopic measurement

There is disclosed a system for detecting and timing the coagulation of blood from a liquid to a clot. The system comprises a vessel containing blood, a member of ferromagnetic material disposed within the vessel, means for providing relative motion between the vessel and the member, and a plurality of Hall effect sensors coupled through the walls of the vessel for sensing the strength of the magnetic flux lines and varying the electrical conductance upon change in the magnetic flux lines when the blood transforms itself and the member changes position relative to the plurality of sensors.

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Bernardsville, NJ, United States of America

Richard Hall